Abstract View

Author(s): Dinesh Kumar Sharma, Bhabani S Nayak

Email(s): dineshs405@gmail.com

Address: Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore, Koraput, Odisha, India
National Center for Natural Resources, Pt. RSU, Raipur.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Cephalosporin is known for its antimicrobial action, concentration-independent bactericidal activity. Cephalosporin has excellent tolerance in children, with almost no dose-related toxicity. These drugs also can be used safely in case of hepatic or renal failure of the infants. Cefpodoxime is the active metabolite of Cefpodoxime Proxetil. It is 3" generation broad spectrum antibiotic. It belongs to - Lactam cephalosporin class of antibiotic. Its administration is through oral route in pediatric and geriatric patients. It is extremely bitter in taste. Cefpodoxime Proxetil is widely used for the treatment or prevention of infectious bacterial diseases. Aim and objectives of this work is to improve the taste of this highly bitter drug Cefpodoxime Proxetil through dispensing in suspension form for the pediatric and geriatric patients. The aim was also to prepare the stable formulation of Cefpodoxime Proxetil suspension and then to compare all the evaluation parameters with marketed formulation. Major challenge in this work is masking of the extreme bitterness of the antibiotic drug for better patient compliance. Approaches used in formulation were taste masking by the use of sweeteners, taste masking by the use of wet granulation and taste masking by the use of dry granulation methods. On the basis of results of preformulation study, we found that there were no incompatibility between drug and excipients so the presumed excipients can be used for formulation development. All in-vitro parameters of the trials were evaluated, out of which dry granulation method has given better result as compared to innovator.

Cite this article:
Sharma and Nayak (2016). Preparation, Stabilization and Taste Making of Dry Powder for Oral Suspension of Cephalosporin Antibiotics. Journal of Ravishankar University (Part-B: Science), 29(1), pp.86-87.


References not available.

Related Images:



Recent Images



Herbal Alternatives for Oral Health:  Mechanistic Exploration with their Market Potential
A Review on Extraction, Identification and Application of Pesticidal Active Phytoderived Metabolites
Determination of Total Dissolved Solids (TDS) of RO Purified Drinking Water Samples in Raipur
Time of the Day Variability in Pit-Building Behavior of Antlion Larvae
A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
Enhanced antioxidant activity in Curcuma caesia Roxb. microrhizomes treated with silver nanoparticles
Studies on the Interaction of Imidazolium Ionic Liquids with Human Serum Albumin
Basic and Advanced Logical Concept Derived from Surface Enhanced Infrared Spectroscopy (SEIRS) as Sensing Probe for Analysis of Chemical Species: A Brief Review
Soil Erosion Risk Estimation by using Semi Empirical RUSLE model: A case study of Maniyari Basin, Chhattisgarh
An Estimator of Population Variance Using Multi-Auxiliary Information

Tags


Recomonded Articles:

Author(s): Preety Shukla; Anindita Roy; Shubha R Sharma

DOI:         Access: Open Access Read More

Author(s): Dinesh Kumar Sharma; Bhabani S Nayak

DOI:         Access: Open Access Read More

Author(s): Rahul Singh; Gunjan Kalyani; Neeraj Kumar Verma; Kamlesh Kumar Dadsena; Rashmi Dwivedi; Nishtha Vaidya; Atanu Kumar Pati; Mitashree Mitra

DOI:         Access: Open Access Read More

Author(s): Sakshi Tiwari Bajaj; S K Taunk; G S Tomar

DOI:         Access: Open Access Read More

Author(s): Kartik T Nakhate; Hemant R Badwaik; Ajazuddin

DOI:         Access: Open Access Read More

Author(s): Manish M. Wanjari; Indu Sikarwar; Yadu Nandan Dey; Ajay Sharma; Sudesh Gaidhani; Ankush Jadhav

DOI:         Access: Open Access Read More

Author(s): Ganjare Anjali; Raut Nishikant

DOI:         Access: Open Access Read More

Author(s): Sanjay Kumar Chelak; Shailendra Saraf

DOI:         Access: Open Access Read More

Author(s): Alpana Ram

DOI:         Access: Open Access Read More

Author(s): Sanjay Daharwal; Anju Anant

DOI:         Access: Open Access Read More

Author(s): Deepak Kumar Mittal; Deepmala Joshi; Sangeeta Shukla

DOI:         Access: Open Access Read More

Author(s): Achla Jain; SD Belsare

DOI:         Access: Open Access Read More