Abstract View

Author(s): Dinesh Kumar Sharma, Bhabani S Nayak

Email(s): dineshs405@gmail.com

Address: Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore, Koraput, Odisha, India
National Center for Natural Resources, Pt. RSU, Raipur.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Cephalosporin is known for its antimicrobial action, concentration-independent bactericidal activity. Cephalosporin has excellent tolerance in children, with almost no dose-related toxicity. These drugs also can be used safely in case of hepatic or renal failure of the infants. Cefpodoxime is the active metabolite of Cefpodoxime Proxetil. It is 3" generation broad spectrum antibiotic. It belongs to - Lactam cephalosporin class of antibiotic. Its administration is through oral route in pediatric and geriatric patients. It is extremely bitter in taste. Cefpodoxime Proxetil is widely used for the treatment or prevention of infectious bacterial diseases. Aim and objectives of this work is to improve the taste of this highly bitter drug Cefpodoxime Proxetil through dispensing in suspension form for the pediatric and geriatric patients. The aim was also to prepare the stable formulation of Cefpodoxime Proxetil suspension and then to compare all the evaluation parameters with marketed formulation. Major challenge in this work is masking of the extreme bitterness of the antibiotic drug for better patient compliance. Approaches used in formulation were taste masking by the use of sweeteners, taste masking by the use of wet granulation and taste masking by the use of dry granulation methods. On the basis of results of preformulation study, we found that there were no incompatibility between drug and excipients so the presumed excipients can be used for formulation development. All in-vitro parameters of the trials were evaluated, out of which dry granulation method has given better result as compared to innovator.

Cite this article:
Sharma and Nayak (2016). Preparation, Stabilization and Taste Making of Dry Powder for Oral Suspension of Cephalosporin Antibiotics. Journal of Ravishankar University (Part-B: Science), 29(1), pp.86-87.


References not available.

Related Images:



Recent Images



Performance Evaluation of Spectrogram Based Epilepsy Detection Techniques Using Gray Scale Features
Perovskite Solar Cells an Efficient, Low Cost, Emerging Photovoltaic Technology
Spectrophotometric Determination of Phenthoate in Vegetables and Fruit Samples of Kabirdham (Chhattisgarh)
Flotation-Dissolution-Spectrophotometric Determination of Phorate in Various Environmental Samples
Preparation, Fabrication and Characterization of Sol-Gel ZnO Thin Films for Organic Solar Cells
Distribution of Some Selected Surface Active Agents (SAAs) in the Aquatic and Global Environment with Their Toxic Impact: A Comprehensive Review
Intriguing Clinical and Pharmaceutical Applications of IERs: A Mini Review
Soil Contamination in the Industrial Vicinity of Bemetara and Raipur District of Chhattisgarh, India
An Extractive Spectrophotometric Method for the Determination of Pymetrozine in Various Ecological Samples of Bilaspur District (C.G.)
Development and Characterization of Quercetin Loaded Nanoparticle for Skin Cancer

Tags


Recomonded Articles:

Author(s): Deepak Kumar Mittal; Deepmala Joshi; Sangeeta Shukla

DOI:         Access: Open Access Read More

Author(s): Ganjare Anjali; Raut Nishikant

DOI:         Access: Open Access Read More

Author(s): Sakshi Tiwari Bajaj; S K Taunk; G S Tomar

DOI:         Access: Open Access Read More

Author(s): Preety Shukla; Anindita Roy; Shubha R Sharma

DOI:         Access: Open Access Read More

Author(s): Ram Kumar Sahu; Pushpa Prasad; Shashikant Chandrakar; Amit Roy

DOI:         Access: Open Access Read More

Author(s): Kartik T Nakhate; Hemant R Badwaik; Ajazuddin

DOI:         Access: Open Access Read More

Author(s): Alpana Ram

DOI:         Access: Open Access Read More

Author(s): Sanjay Kumar Chelak; Shailendra Saraf

DOI:         Access: Open Access Read More

Author(s): Sanmoy Karmakar

DOI:         Access: Open Access Read More

Author(s): Manish M. Wanjari; Indu Sikarwar; Yadu Nandan Dey; Ajay Sharma; Sudesh Gaidhani; Ankush Jadhav

DOI:         Access: Open Access Read More

Author(s): Shikha Srivastava; Manju R Singh; Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Rahul Singh; Gunjan Kalyani; Neeraj Kumar Verma; Kamlesh Kumar Dadsena; Rashmi Dwivedi; Nishtha Vaidya; Atanu Kumar Pati; Mitashree Mitra

DOI:         Access: Open Access Read More