Author(s):
Dinesh Kumar Sharma, Bhabani S Nayak
Email(s):
dineshs405@gmail.com
Address:
Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore, Koraput, Odisha, India
National Center for Natural Resources, Pt. RSU, Raipur.
Published In:
Volume - 29,
Issue - 1,
Year - 2016
DOI:
Not Available
ABSTRACT:
Cephalosporin is known for its antimicrobial action, concentration-independent bactericidal activity. Cephalosporin has excellent tolerance in children, with almost no dose-related toxicity. These drugs also can be used safely in case of hepatic or renal failure of the infants. Cefpodoxime is the active metabolite of Cefpodoxime Proxetil. It is 3" generation broad spectrum antibiotic. It belongs to - Lactam cephalosporin class of antibiotic. Its administration is through oral route in pediatric and geriatric patients. It is extremely bitter in taste. Cefpodoxime Proxetil is widely used for the treatment or prevention of infectious bacterial diseases. Aim and objectives of this work is to improve the taste of this highly bitter drug Cefpodoxime Proxetil through dispensing in suspension form for the pediatric and geriatric patients. The aim was also to prepare the stable formulation of Cefpodoxime Proxetil suspension and then to compare all the evaluation parameters with marketed formulation. Major challenge in this work is masking of the extreme bitterness of the antibiotic drug for better patient compliance. Approaches used in formulation were taste masking by the use of sweeteners, taste masking by the use of wet granulation and taste masking by the use of dry granulation methods. On the basis of results of preformulation study, we found that there were no incompatibility between drug and excipients so the presumed excipients can be used for formulation development. All in-vitro parameters of the trials were evaluated, out of which dry granulation method has given better result as compared to innovator.
Cite this article:
Sharma and Nayak (2016). Preparation, Stabilization and Taste Making of Dry Powder for Oral Suspension of Cephalosporin Antibiotics. Journal of Ravishankar University (Part-B: Science), 29(1), pp.86-87.