Abstract View

Author(s): Kartik T Nakhate, Hemant R Badwaik, Ajazuddin

Email(s): kartiknakhate@gmail.com

Address: Rungta College of Pharmaceutical Sciences & Research, Kohka-Kurud Road, Bhilai 490 024, C.G, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

Plumbagin is a medicinally important alkaloid obtained from the Plumbago zeylanica L. root. In recent studies, the alkaloid showed neuroprotective and antidepressant-like activities. Therefore, in the present investigation, the effect of plumbagin on anxiety-related behavior was screened using social interaction paradigm in mice. Adult male Swiss Albine mice were divided in different groups. In first series of study, the animals were administered with vehicle (control), different doses of plumbagin (4, 8 and 12 mg/kg) and diazepam (0.5, 1 and 2 mg/kg) via intraperitoncal route, and 15 min afterwards they were subjected to social interaction test. Furthermore, the modulation of anxiety-related behavior of plumbagin by diazepam, if any, was examined. Plumbagin per se treated mice showed increase in social interaction time in a dose dependent manner as compared with that in control animals. This suggests the antianxiety-like effect of plumbagin. Similar to plumbagin, treatment with diazepam also produced dose dependent increase in social interaction time, which confirms its anxiolytic activity. In combination studies, 10 min prior administration of subeffective dose of diazepam (0.5 mgkg) potentiated the antianxiety-like effect of plumbagin (4 and 8 mg/kg). Since diazepam produces anxiolytic effect by activating endogenous GABAergic system, the present data raise the possibility that plumbagine might have the modulatory effect on the endogenous GABAergic system, which clearly merits further investigations. The results of the current study, for the fint time, suggest the antianxiety-like action of plumbagin. Moreover, the effect of alkaloid might be attributed to the enhancement of GABArgic tone in the brain.

Cite this article:
Nakhate, Badwaik and Ajazuddin (2016). Evaluation of Antianxiety-Like Activity of Plumbagin and its Combination with Diazepam in Mice. Journal of Ravishankar University (Part-B: Science), 29(1), pp.81-82.

References not available.

Related Images:

Recent Images

Modeling of Abnormal Hysteresis in CsPbBr3 based Perovskite Solar Cells
Impact of Melatonin on Growth and Antioxidant Activity of Cicer arietinum L. Grown under Arsenic Stress
Assessment of Cymoxanil in Soil, Water and Vegetable Samples
Need of Gallium Recovery from Waste Samples: A Review
Higher Order Statistics Based Blind Steg analysis using Deep Learning
Covid-19 related School Closure Impact on School going Children & Adolescents of Raipur, Chhattisgarh
Determination of Pentachlorophenol in Environmental Samples by Spectrophotometry
Simple and Cost Effective Polymer Modified Gold Nanoparticles Based on Colorimetric Determination of L-Cysteine in Food Samples
Investigation on Design and Device Modeling of High Performance CH3NH3PbI3-xClx Perovskite Solar Cells
Remotely Sensed Image Based on Robust Segmentation and GIS System


Recomonded Articles:

Author(s): Krishna Yadav*; Jyoti Pawar; Deependra Singh; Manju Rawat Singh

DOI: 10.52228/JRUB.2018-31-1-2         Access: Open Access Read More

Author(s): Preety Shukla; Anindita Roy; Shubha R Sharma

DOI:         Access: Open Access Read More

Author(s): Mrinal Sharma; Anuma Singh; Latha Rangan; Anil M Limaye

DOI:         Access: Open Access Read More

Author(s): Deepti Tikariha; Jyotsna Lakra; Srishti Dutta Roy; Toshikee Yadav; Kallol KGhosh

DOI:         Access: Open Access Read More

Author(s): Sakshi Tiwari Bajaj; S K Taunk; G S Tomar

DOI:         Access: Open Access Read More

Author(s): Ganjare Anjali; Raut Nishikant

DOI:         Access: Open Access Read More

Author(s): Deepak Kumar Mittal; Deepmala Joshi; Sangeeta Shukla

DOI:         Access: Open Access Read More

Author(s): Rahul Singh; Gunjan Kalyani; Neeraj Kumar Verma; Kamlesh Kumar Dadsena; Rashmi Dwivedi; Nishtha Vaidya; Atanu Kumar Pati; Mitashree Mitra

DOI:         Access: Open Access Read More

Author(s): E Susithra; D Chamundeswari; Padma Srikanth; Rajasekhar Chekkara; B Sesha Poornima

DOI:         Access: Open Access Read More

Author(s): Manish M. Wanjari; Indu Sikarwar; Yadu Nandan Dey; Ajay Sharma; Sudesh Gaidhani; Ankush Jadhav

DOI:         Access: Open Access Read More

Author(s): Minakshi Waghmare; Kalyani Kale; Deepti Bhagchandani; Shekhar Waikar

DOI:         Access: Open Access Read More

Author(s): Anand Kar; Sunanda Panda

DOI:         Access: Open Access Read More

Author(s): Ram Kumar Sahu; Pushpa Prasad; Shashikant Chandrakar; Amit Roy

DOI:         Access: Open Access Read More