Abstract View

Author(s): Richa Shri, Kundan Singh Bora, Abhishek Bhanot, Rahul Kumar, Amit Kumar

Email(s): rshri587@hotmail.com

Address: Department of Pharmaceutical Sciences and Drug Rescarch, Punjabi University, Patiala - 147 002, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Neuroprotection' means preserving the function and structure of neurons and salvaging neurons threatened by disease or injury. Neuroprotection is considered an adjunctive treatment option for neurodegenerative disorders. Oxidative stress is a major culprit in neurological disorders; hence one of the current of treatment strategies includes use of antioxidants. Plants are a rich source of antioxidant phytoconstituents. One such plant - Allium cepa L., or onion, (family Alliaceae) is a potent antioxidant. In our laboratory we have explored and successfully demonstrated the neuroprotective effect of extracts of onions in animal models of ischemic stroke, diabetic neuropathy and neuropathic pain. In pre and post- ischemic stroke model the methanol extract prepared from the outer scales of onion bulbs (MEOS) prevented memory loss and motor in-coordination, reduced oxidative stress and cerebral infarct size (1-2). The MEOS also prevented development of diabetic neuropathy (DN) as well as showed improvement after the onset of DN (3). MEOS of red variety of onions have also shown significant improvement in chronic constriction induced model of neuropathic pain. Red onions with higher amounts of flavonoids as compared to the white onions produced more significant neuroprotection. Also the extract of outer scales of red variety demonstrated the most significant neuroprotective effect (4).The part of onions that is generally discarded - the outer scales of the bulbs, have great potential for prevention as well as for treatment of neuronal disorders. Thus, this commonly used vegetable maybe developed as a valuable neuroprotective agent.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Herbal Alternatives for Oral Health:  Mechanistic Exploration with their Market Potential
Time of the Day Variability in Pit-Building Behavior of Antlion Larvae
A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
Enhanced antioxidant activity in Curcuma caesia Roxb. microrhizomes treated with silver nanoparticles
Studies on the Interaction of Imidazolium Ionic Liquids with Human Serum Albumin
Basic and Advanced Logical Concept Derived from Surface Enhanced Infrared Spectroscopy (SEIRS) as Sensing Probe for Analysis of Chemical Species: A Brief Review
Soil Erosion Risk Estimation by using Semi Empirical RUSLE model: A case study of Maniyari Basin, Chhattisgarh
An Estimator of Population Variance Using Multi-Auxiliary Information
Microemulsion as Novel Drug Delivery for Fungal Eye Infection
Potential of Bioactive Compounds for Atopic Dermatitis

Tags


Recomonded Articles: