ABSTRACT:
The aim of the present work was to design and develop Naringenin (NGN) loaded solid lipid nanoparticles (NGN- SLN) to improve the oral bioavailability by intestinal lymphatic delivery. Naringenin (4', 5, 7-trihydroxyflavanone) is a citrus flavonoid mainly obtaincd from the citrus fruits. It degrades in low pH and enzymatic condition of gastrointestinal tract having very low oral absolute bioavailability about 8% along with 2-3h half-life. The NGN-SLN was composed of riglycerides, lecithin and various aqueous surfactants, were optimized using hot homogenization followed by ultrasonication method. The optimized SLN had particle size of 110:5.48 nm, EE of 91.317 83% and zeta potential 33.52.11mV.The drug release of NGN SLN showed initial burst release followed by the sustained release. TEM stady confirmed the almost spherical in shape. Solid state characterization using differential scanning calorimeter (DSC) and powder X-ray diffraction (PXRD) analysis confirmed the homogeneous distribution of NGN within the lipid matrix. The 5.25 fold increase in AUC after intraduodenal administration of NGN-SLN in rats treated with saline in comparison to rats treated with cycloheximide (a blocker of intestinal lymphatic pathway), confirmed its intestinal lymphatic delivery. On the above experimental results indicate that SLN may offer a promising strategy for improving the oral bioavailability of therapeutic agents.
Cite this article:
Sahu and Jain (2016). Enhanced Oral Bioavailability of Plant Active Naringenin through Solid Lipid Nanoparticulate Carrierby Intestinal Lymphatic Delivery. Journal of Ravishankar University (Part-B: Science), 29(1), pp.114-115.