Abstract View

Author(s): Awanish Kumar, Parul Thakur

Email(s): parulthakur507@gmail.com

Address: Department of Biotechnology, NIT Raipur, Chhattisgarh, India
Oils Oleochemicals & Surfactant Technology, ICT Mumbai, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Nature is a huge enigma, having an inexhaustible plate of mysteries to fill man's insatiable thirst of knowledge Two such products of nature, alginate and chitosan, have potential to be used in wide variety of encapsulated drug formulations. Diabetes Mellitus is a multi-factorial and multi-consequential chronic metabolic disorder with the hallmark feature of hyperglycaemia. Current therapy through oral anti-diabetic drugs and subcutaneous administration of insulin suffers from serious disadvantages of occasional hypoglycaemia due to unmonitored dosage and lipoatrophy. These approaches don't mimic normal physiological pattern of insulin release. Thus, bio-compatible oral insulin formulations, if made possible, would prove to be a boon. This preliminary study included 100IU insulin encapsulated in 1% CS (in 5% acetic acid) + 2% ALG (in 2% CaCl). Insulin encapsulated CS ALG beads were prepared by simple extrusion method. At pH 74 (intestinal), swelling ratio of coated beads is significantly higher indicating that this formulation can be used for intestinal peptide drug delivery. SEM gave an average size of 30-50mm.Also, shift of characteristic bond peaks in FTIR spectra of CS/ALGINS loaded beads is indicative of insulin encapsulation. Nitrogen in EDX results validates the interaction between chitosan and alginate, hence, the blending. Release rate graph suggests, in 9hrs maximum cumulative release achieved was near to 20%. Entrapment Efficiency of beads was calculated as 39%. Therefore, release was about 50%. The best linearity, with R'-0.85, was found in Higuchi's equation plot indicating the release of drug from matrix as a square root of time dependent process based on Fickian diffusion. Korsmeyer Peppas model, n>0.89, suggest release mechanism to be Super Case II Transport.

Cite this article:
Kumar and Thakur (2016). A Bio-Ethnopharmacology Approach: Development and Characterization of Chitosan-Alginate Polymeric Formulation for Oral Insulin Administration. Journal of Ravishankar University (Part-B: Science), 29(1), pp.70-71.


References not available.

Related Images:



Recent Images



Study of the Enhanced Efficiency of Crystalline Silicon Solar Cells by Optimizing Anti Reflecting Coating using PC1D Simulation
Formulation of Topical Itraconazole Nanostructured Lipid Carriers (Nlc) Gel for Onychomycosis
Cosmetic Testing Equipment: Device and Types of Equipment for Dermatological Evaluation for Women’s Skin
Oxidative stress: Insights into the Pathogenesis and Treatment of Alopecia
UV Spectroscopy Analysis for Itraconazole
Challenges and Potential of Perovskite Solar Cells
Kinetic Study of Solvent Effect on the Hydrolysis of  Mono-3, 5-Dimethylaniline Phosphate
OLED: New Generation Display Technology
Parametric study of AlGAN/GaN UV-Led Based on Quantum Confined Stark Effect (QCSE)
Analysis of High Efficient Perovskite Solar Cells Using Machine Learning

Tags


Recomonded Articles:

Author(s): Surendra G Gattani; Ravina Shete; Sandeep Ambore

DOI:         Access: Open Access Read More

Author(s): Naman Shukla; K. Anil Kumar; Madhu Allalla; Sanjay Tiwari

DOI: 10.52228/JRUB.2022-35-1-2         Access: Open Access Read More

Author(s): Manas Kanti Deb; Mithlesh Mahilang; Jayant Nirmalkar

DOI: 10.52228/JRUB.2017-30-1-2         Access: Open Access Read More

Author(s): Preety Shukla; Anindita Roy; Shubha R Sharma

DOI:         Access: Open Access Read More

Author(s): AR Sood and RC Rathor

DOI:         Access: Open Access Read More

Author(s): Srishti Verma; Visheshta Valvi; Kamlesh Kumar Shukla

DOI: 10.52228/JRUB.2022-35-1-6         Access: Open Access Read More

Author(s): Dinesh Kumar Sharma; Bhabani S Nayak

DOI:         Access: Open Access Read More

Author(s): D.K. Sen; S. Bhushan

DOI:         Access: Open Access Read More

Author(s): R.Singh; U.C. Singh

DOI:         Access: Open Access Read More

Author(s): Armiya Sultan; Saba Taj; Vivek Choudhary; Arti Parganiha

DOI: 10.52228/JRUB.2017-30-1-14         Access: Open Access Read More

Author(s): Sakshi Tiwari Bajaj; S K Taunk; G S Tomar

DOI:         Access: Open Access Read More