Abstract View

Author(s): Alpana Ram

Email(s): ramalpana@redifmail.com

Address: Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur - 495 009, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Sitopaladichurna has been in use in Indian Traditional Medicine Ayurveda since antiquity and is still in wide use. The aim was to estimate its major constituent Piperine, in plasma. HPLC as well as gas chromatography methods for analysis of Piperine in peppers, pepper extract and oleoresin have been reported, but there is no sensitive and reproducible method for quantification of Piperine in body fluids of any formulations. Sitopaladichurna (200 mg/kg) was administered orally to six rats. Blood (1 ml) was collected from each animal and immediately extracted with of ethyl acetate, centrifuged, dried over anhydrous sodium sulphate. The cethyl acetate was then evaporated under a stream of nitrogen at 50°C, The residue was hrs. Plasma was immediately separated by centrifuged and analyzed the same day. Piperine could be detected in plasma from 05 to 8 hours after administration with maximum plasma concentration (2.80 – 1.76 ug/ml) at 0.5 - 1 h post dosing. Piperine is rapidly absorbed through the gastrointestinal tract and could be detected in plasma as early as 50 min after administration.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Performance Evaluation of Spectrogram Based Epilepsy Detection Techniques Using Gray Scale Features
Perovskite Solar Cells an Efficient, Low Cost, Emerging Photovoltaic Technology
Spectrophotometric Determination of Phenthoate in Vegetables and Fruit Samples of Kabirdham (Chhattisgarh)
Flotation-Dissolution-Spectrophotometric Determination of Phorate in Various Environmental Samples
Preparation, Fabrication and Characterization of Sol-Gel ZnO Thin Films for Organic Solar Cells
Distribution of Some Selected Surface Active Agents (SAAs) in the Aquatic and Global Environment with Their Toxic Impact: A Comprehensive Review
Intriguing Clinical and Pharmaceutical Applications of IERs: A Mini Review
Soil Contamination in the Industrial Vicinity of Bemetara and Raipur District of Chhattisgarh, India
An Extractive Spectrophotometric Method for the Determination of Pymetrozine in Various Ecological Samples of Bilaspur District (C.G.)
Development and Characterization of Quercetin Loaded Nanoparticle for Skin Cancer

Tags


Recomonded Articles: