Abstract View

Author(s): Rajni Kant Panik, Manju Singh, Deependra Singh

Email(s): panik.143@gmail.com

Address: University Institute of Pharmacy, Pr. Ravishankar Shukla University, Raipur - 492 010, Chhattisgarh.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Present work was based with objective to optimize formulations of mupirocin loaded PLGA nanocarriers using response surface methodology (RSM). The miscellaneous design model (two-factor three level factorial design) was used for optimization of formulations was considered for optimization. There were three parameters, drug entrapment efficiency (EE), drug loading (DL) percentage, and mean particle size of drug loaded nanocarrier, considered for investigating the optimal formulation with respect to two independent variables, including drug concentration (XI) and polymer concentration (X2). The result showed that the optimal nanocarrier was composed of drug concentration(XI) 10mg and polymer concentration (X2) 20 mg with %EE of 85.46 t 4.01%, DL of 30.2520.76, mean particle size of 120.24554 nm, polydispersity index (PDI) of 0.20320.067, and zeta potential value of -8.672(-4.45) mV. DSC and TEM study showed that there was no chemical interaction between mupirocin and polymer (PLGA) and the mupirocin- PLGA nanoparticle are non spherical, respectively. The drug release experiments exhibited a sustained release over during 24 h, up to 60.26 z 2.83%. Accelerated stability studies showed that there was no significant change occurring in the responses after storage condition for a total period of 3 months.

Cite this article:
Panik, Singh and Singh (2016). Preparation and Characterization of PLGA Nanoparticle: Formulation and Optimization through Entrapment Efficiency, Drug Loading and Particle Size. Journal of Ravishankar University (Part-B: Science), 29(1), pp.76-77.


References not available.

Related Images:



Recent Images



Chlorpyrifos Mediated Amendment in Protein Profiling of Bacillus spp.
Structural, Compositional and Photoluminescence Studies of Li4SrCa(SiO4)2: Eu3+ Red Phosphor Synthesized by Solid State Reaction Method
Formulation and Characterization of Magnetically Responsive Mesalamine Microspheres for Colon Targeting
Development of Non-Invasive Technique for Heart Rate Detection Using Facial Videos
Human Part Semantic Segmentation Using CDGNET Architecture for Human Activity Recognition
Lifestyle Modification Therapy and its Effect on Weight Status of Non-Alcoholic Male Liver Disease Patients
Exploring Life Cycle Analysis in Developing Sustainable Communities in Chhattisgarh
Monitoring the Concentration of Lead in the Industrial Wastewater of Baloda Bazar District
Impact of Climate Change on Paddy Yield in Bastar District of Chhattisgarh
Chemical Pollutants: A Concern to The Environment

Tags


Recomonded Articles:

Author(s): Beeta Rani Khalkho; Anushree Saha; Bhuneshwari Sahu; Manas Kanti Deb*

DOI: 10.52228/JRUB.2021-34-1-6         Access: Open Access Read More

Author(s): Nikita Verma; Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Shweta Sao; Hemlata Nishad

DOI:         Access: Open Access Read More

Author(s): Prameet Singh; Preeti K Suresh

DOI:         Access: Open Access Read More

Author(s): Manmohan S Jangdey; Anshita Gupta; Shailendra Saraf; Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Sanjay Daharwal; Anju Anant

DOI:         Access: Open Access Read More

Author(s): Nivedita Gautam; Preeti K Suresh

DOI:         Access: Open Access Read More

Author(s): Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Renu Bhatt; Neha Pandey

DOI:         Access: Open Access Read More

Author(s): Suprit D Saoji; Aniket Rode; Vikas Saoji; Veena S Belgamwar

DOI:         Access: Open Access Read More

Author(s): Manmohan L Satnami; Kuleshwar Patel; Sandeep K Vaishnav; Kumudini Chandraker; Jyoti Korram; Rekha Nagwanshi; Kallol K Ghosh

DOI:         Access: Open Access Read More

Author(s): Bina Gidwani; Amber Vyas; Chanchal Deep Kaur

DOI:         Access: Open Access Read More