Abstract View

Author(s): Rajni Kant Panik, Manju Singh, Deependra Singh

Email(s): panik.143@gmail.com

Address: University Institute of Pharmacy, Pr. Ravishankar Shukla University, Raipur - 492 010, Chhattisgarh.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Present work was based with objective to optimize formulations of mupirocin loaded PLGA nanocarriers using response surface methodology (RSM). The miscellaneous design model (two-factor three level factorial design) was used for optimization of formulations was considered for optimization. There were three parameters, drug entrapment efficiency (EE), drug loading (DL) percentage, and mean particle size of drug loaded nanocarrier, considered for investigating the optimal formulation with respect to two independent variables, including drug concentration (XI) and polymer concentration (X2). The result showed that the optimal nanocarrier was composed of drug concentration(XI) 10mg and polymer concentration (X2) 20 mg with %EE of 85.46 t 4.01%, DL of 30.2520.76, mean particle size of 120.24554 nm, polydispersity index (PDI) of 0.20320.067, and zeta potential value of -8.672(-4.45) mV. DSC and TEM study showed that there was no chemical interaction between mupirocin and polymer (PLGA) and the mupirocin- PLGA nanoparticle are non spherical, respectively. The drug release experiments exhibited a sustained release over during 24 h, up to 60.26 z 2.83%. Accelerated stability studies showed that there was no significant change occurring in the responses after storage condition for a total period of 3 months.

Cite this article:
Panik, Singh and Singh (2016). Preparation and Characterization of PLGA Nanoparticle: Formulation and Optimization through Entrapment Efficiency, Drug Loading and Particle Size. Journal of Ravishankar University (Part-B: Science), 29(1), pp.76-77.


References not available.

Related Images:



Recent Images



Modeling of Abnormal Hysteresis in CsPbBr3 based Perovskite Solar Cells
Impact of Melatonin on Growth and Antioxidant Activity of Cicer arietinum L. Grown under Arsenic Stress
Assessment of Cymoxanil in Soil, Water and Vegetable Samples
Need of Gallium Recovery from Waste Samples: A Review
Higher Order Statistics Based Blind Steg analysis using Deep Learning
Covid-19 related School Closure Impact on School going Children & Adolescents of Raipur, Chhattisgarh
Determination of Pentachlorophenol in Environmental Samples by Spectrophotometry
Simple and Cost Effective Polymer Modified Gold Nanoparticles Based on Colorimetric Determination of L-Cysteine in Food Samples
Investigation on Design and Device Modeling of High Performance CH3NH3PbI3-xClx Perovskite Solar Cells
Remotely Sensed Image Based on Robust Segmentation and GIS System

Tags


Recomonded Articles:

Author(s): Beeta Rani Khalkho; Anushree Saha; Bhuneshwari Sahu; Manas Kanti Deb*

DOI: 10.52228/JRUB.2021-34-1-6         Access: Open Access Read More

Author(s): Prameet Singh; Preeti K Suresh

DOI:         Access: Open Access Read More

Author(s): Shweta Sao; Hemlata Nishad

DOI:         Access: Open Access Read More

Author(s): Manmohan L Satnami; Kuleshwar Patel; Sandeep K Vaishnav; Kumudini Chandraker; Jyoti Korram; Rekha Nagwanshi; Kallol K Ghosh

DOI:         Access: Open Access Read More

Author(s): Nikita Verma; Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Chanchal Deep Kaur

DOI:         Access: Open Access Read More

Author(s): Suprit D Saoji; Aniket Rode; Vikas Saoji; Veena S Belgamwar

DOI:         Access: Open Access Read More

Author(s): Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Manmohan S Jangdey; Anshita Gupta; Shailendra Saraf; Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Renu Bhatt; Neha Pandey

DOI:         Access: Open Access Read More

Author(s): Sanjay Daharwal; Anju Anant

DOI:         Access: Open Access Read More

Author(s): Nivedita Gautam; Preeti K Suresh

DOI:         Access: Open Access Read More