Abstract View

Author(s): Nivedita Gautam, Preeti K Suresh

Email(s): gautamnivedita89@gmail.com

Address: Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur - 495 006, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

Osteoporosis is a major problem worldwide especially in postmenopausal women and is treated with bisphosphonates. The drug belongs to BCS class II, and thus has high solubility and low permeability and has severe gastric ulceration side effects. To overcome these problems Risedronate (drug) loaded in microsphere in an enteric coated formulation were prepared. Microparticles were prepared by simple emulsification technique based on glutaraldehyde crosslinking and were coated with Eudragit L-100. The microspheres were characterized for entrapment efficiency, drug loading, in vitro drug release, surface morphology, as well as particle size analysis, and FTIR spectroscopy. Particle sizes, as measured by the optical microscopic technique, were of an average size in the range 200 um to 320 um with drug content 5.02- 9.88 and entrapment efficiency upto 82%. FTIR data signifies no interaction between the drug and polymer used. In vitro release studies were performed into phosphate buffers (pH 1.2 for 2 hr and pH 6.8 at 37°C) as a function of cross linking coating density of the microspheres. Less than 10 % release was at pH 1.2 which confirms the enteric coating of microsphers. Drug release was in the range of 65- 80% in 6 hrs and follows Higuchi release kinetics. The findings of the present study conclusively state that enteric coated microspheres of Risedronate are potential for restricting drug release in stomach and sustained drug delivery in intestinal region avoiding the gastric iritation effect of Risedronate.

Cite this article:
Gautam and Suresh (2016). Enteric Coated Microparticulate System: Novel Approach for the Treatment of Osteoporosis. Journal of Ravishankar University (Part-B: Science), 29(1), pp.152-153.

References not available.

Related Images:

Recent Images

Chlorpyrifos Mediated Amendment in Protein Profiling of Bacillus spp.
Structural, Compositional and Photoluminescence Studies of Li4SrCa(SiO4)2: Eu3+ Red Phosphor Synthesized by Solid State Reaction Method
Formulation and Characterization of Magnetically Responsive Mesalamine Microspheres for Colon Targeting
Development of Non-Invasive Technique for Heart Rate Detection Using Facial Videos
Human Part Semantic Segmentation Using CDGNET Architecture for Human Activity Recognition
Lifestyle Modification Therapy and its Effect on Weight Status of Non-Alcoholic Male Liver Disease Patients
Exploring Life Cycle Analysis in Developing Sustainable Communities in Chhattisgarh
Monitoring the Concentration of Lead in the Industrial Wastewater of Baloda Bazar District
Impact of Climate Change on Paddy Yield in Bastar District of Chhattisgarh
Chemical Pollutants: A Concern to The Environment


Recomonded Articles:

Author(s): Rajendra Jangde; Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Nivedita Gautam; Preeti K Suresh

DOI:         Access: Open Access Read More

Author(s): Shruti Rathor; Alpana Ram

DOI:         Access: Open Access Read More

Author(s): Chanchal Deep Kaur

DOI:         Access: Open Access Read More

Author(s): Bakhle Suparna; Avari Jasmine

DOI:         Access: Open Access Read More

Author(s): Amit Alexander; Ajazuddin

DOI:         Access: Open Access Read More