Abstract View

Author(s): Bakhle Suparna, Avari Jasmine

Email(s): suparna_bakhle@yahoo.co.in

Address: Pharmaceutics Division, Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur-440033.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
This study describes the formulation and evaluation of solid self-emulsifying drug delivery system (SEDDS) as a novel technique to efficiently deliver poorly water soluble drug candidate with the objective of improvement in solubility, dissolution and absorption. An anti hyperlipidemic drug candidate was employed determined in various vehicles including oils, surfactants and co-surfactants. Pseudoternary phase diagrams were constructed using Labrafil M 1944 as oil phase, Acrysol EL 135 and Lauroglycol 90 as the surfactant combination to identify the most efficient self-microemulsification region. SEDDS were formulated and evaluated for emulsification time, droplet size, zeta potential, drug content, optical clarity, in vitro dissolution and invitro absorption. The optimized SEDDS was solidified using Neusilin US2 as the adsorbent and evaluated for solid properties. In vivo performance of optimized solid-SEDDS of LVS was determined in terms of hypolipidemic activity. The optimized formulation for the drug was found to have nano scale droplet size and total phase clarity on dilution with water. The in vitro dissolution and in vitro absorption studies through everted rat intestinal segment showed improved dissolution and absorption of drug from SEDDS compared to its aqueous suspension. Solid self-emulsifying powder retained the self-emulsifying property of the liquid SEDDS. Also Solid-SEDDS of the drug showed a significantly better in vivo performance than plain suspension in term of pharmacodynamics parameters. The study demonstrates that self-emulsifying drug delivery system is a promising strategy for improving the solubility, dissolution and absorption of poorly soluble APL. the studies. Solubility of the drug was.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Herbal Alternatives for Oral Health:  Mechanistic Exploration with their Market Potential
Time of the Day Variability in Pit-Building Behavior of Antlion Larvae
A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
Enhanced antioxidant activity in Curcuma caesia Roxb. microrhizomes treated with silver nanoparticles
Studies on the Interaction of Imidazolium Ionic Liquids with Human Serum Albumin
Basic and Advanced Logical Concept Derived from Surface Enhanced Infrared Spectroscopy (SEIRS) as Sensing Probe for Analysis of Chemical Species: A Brief Review
Soil Erosion Risk Estimation by using Semi Empirical RUSLE model: A case study of Maniyari Basin, Chhattisgarh
An Estimator of Population Variance Using Multi-Auxiliary Information
Microemulsion as Novel Drug Delivery for Fungal Eye Infection
Potential of Bioactive Compounds for Atopic Dermatitis

Tags


Recomonded Articles: