Abstract View

Author(s): Chanchal Deep Kaur

Email(s): dr.chanchaldeep@gmail.com

Address: Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg. CG, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016


Lymphatic disorders are vital problem in front of drug delivery cargoes because of their specific tissues and drainage system. Lymphatic disorders need an advanced delivery system which can reach there and deliver the drug. Novel lipid-based nanoformulations, such as solid lipid nanoparticles and nanostructured lipid carriers, have unique characteristics that make them promising candidates for lymphatic delivery. In present study, surface modified Lopinavir loaded solid lipid nanoparticles (MA-Lo-SLN) were formulated by hot homogenization process. The formulated SLN (MA-Lo-SLN) was found to exhibit a mean particle size of 220 nm (polydispersity index, PDI<0.27) and zeta potential was found to be between -25mV to -28mV. Particles were characterized using differential scanning calorimetry (DSC), XRD and SEM studies to confirm their structural morphology and the homogeneous distribution of drug within the lipid matrix. In vitro release studies at pH 6.8 phosphate buffer (PBS) showed a slow but sustained release profile of drug. Fluorescence microscopy was done to confirm the lymphatic targeting. The study results confirm that the MA-Lo-SLN exhibits desired characteristic for targeting lymphatic system.

Cite this article:
Not Available

References not available.

Related Images:

Recent Images

Modeling of Abnormal Hysteresis in CsPbBr3 based Perovskite Solar Cells
Impact of Melatonin on Growth and Antioxidant Activity of Cicer arietinum L. Grown under Arsenic Stress
Assessment of Cymoxanil in Soil, Water and Vegetable Samples
Need of Gallium Recovery from Waste Samples: A Review
Higher Order Statistics Based Blind Steg analysis using Deep Learning
Covid-19 related School Closure Impact on School going Children & Adolescents of Raipur, Chhattisgarh
Determination of Pentachlorophenol in Environmental Samples by Spectrophotometry
Simple and Cost Effective Polymer Modified Gold Nanoparticles Based on Colorimetric Determination of L-Cysteine in Food Samples
Investigation on Design and Device Modeling of High Performance CH3NH3PbI3-xClx Perovskite Solar Cells
Remotely Sensed Image Based on Robust Segmentation and GIS System


Recomonded Articles: