Drugs having poor solubility always be a challenged to the scientists and researchers, to overcome such problem lipid based self-micro emulsifying drug delivery systems (SMEDDS) is a novel and better option for increasing the oral bioavailability of such drugs. From the viewpoint of oral drug delivery, natural lipids are studied as components of vanous oily liquids and dispersions that are designed to increase solubility and bioavailability of drugs belonging to the class Il and IV of the biopharmaceutical drug classification system The present study was to develop and to evaluate a SMEDDS formulation for the drug Domperidone which is basically a poorly water soluble drug. For the selection of formulation components, the solubility of Domperidone was screened in different oils. The drug was found to be more soluble in neem oil and thus chosen as optimized oil for the study. To this system i.e. (Neem oil), a surfactant (Tween 20), a co surfactant (PEG 400), and a co solvent (ethanol) was used and evaluated to identify microemulsion domain through ternary phase diagram. The SMEDDS were characterized for robustness to dilution, viscosity, emulsification time, drug content were studied following their addition to water under gentle agitation. The prepared Domperidone SMEDDS is having low oil quantity and a permitted amount of surfactant showing good result throughout It was concluded that SMEDDS prepared with neem oil. tween 20 and (PEG 400: ethanol) and surfactant co-surfactant ratio (4:1) is a promising approach to improve the solubility and dissolution rate of Domperidone.
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