ABSTRACT:
A wound is defined as a defect or break in the skin, resulting from physical or thermal damage or as a result of the presence of an underlying medical or physical condition. We aimed to develop a biocompatible, biodegradable and controlled release of quercetin loaded liposomal formulation. Liposomes quercetin (Qu) was prepared thin-film hydration method by optimizing ratio of active drugs and soya phospholipids. The prepared liposomes was characterized by in vitro studies like in vitro release study, particle size, wound contraction, excision wound model. Histopathological study showed significant (pc0.06) increase in fibroblast cells, collagen fibers and blood vessels formation. All parameters such as wound contraction, tensile strength, histopathological and biochemical parameters- hydroxyproline content, protein level, etc. were observed significant (pc0.06), SEM study of liposomes is porous morphology, wound contraction 95.52+0.37%, diffusion coefficient=1.71x10-5 cm2/s, in vitro release study 95.32%. Present results suggest an accelerated re-epithelialization under moist wound environment with delivery of quercetin effective at different stages of wound healing cascade with minimum disturbance of wound bed. It provides a direct continuous or sustained release of the antimicrobial and debriding agent at the wound surface.