Abstract View

Author(s): Manmohan S Jangdey, Anshita Gupta, Shailendra Saraf, Swarnlata Saraf

Email(s): swarnlata_saraf@rediffmail.com

Address: University Institute of Pharmacy, P. Ravishankar Shukla University, Raipur-492010, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
The aim of this study was to develop a potential novel formulation of nanoemulsion containing apigenin using tamarind gum polymeric emulsifier which was having the smallest droplet size, the highest loading, and a good physical stability for Skin delivery, Nanoemulsion containing apigenin have prepared by high specd homogenization and characterized for morphology, zeta potential, differential scanning calorimeter study and penetration studies. In vitro skin permeation of nanoemulsion encapsulated apigenin through goat abdominal skin was determined by the Franz diffusion cell and confocal laser scanning microscope (CLSM). The cytotoxicity of the reported formulation was evaluated in HaCaT Cells (A) and A431 cells (B) by MTT assay. The nanoemulsions were characterized by TEM demonstrated spherical droplets and FTIR to ensure the compatibility among its ingredients. Low fluorescence intensity in CLSM indicated lower cumulative amount of drug permeation from marketed product. CLSM showed uniform fluorescence intensity across the entire depth of skin in nanocarrier treatment, indicating high penetrability of nanoemulsion gel through goat skin. The nanoemulsion gel showed toxicity on melanoma (A341) in a concentration range of 0.4-2.0 mg/ml, but less toxicity toward HaCaT cells by MTT assay. The nanoemulsion gel formulation of apigenin possesses better penetrability across goat skin as compared to marketed formulation. Hence, it can be concluded that novel formulation of apigenin can be proved fruitful for the treatment of skin cancer in near future.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Potential of Bioactive Compounds for Atopic Dermatitis
Time-Frequency Image-based Speech Emotion Recognition using Artificial Neural Network
Zn Fortification Influential Impact on the Productivity of Calocybe indica Mycelium
Enhanced ACO in clustering algorithm for QoS in WSN enabled IoT
A Modified Regression Type Estimator Using Two Auxiliary Variables
Sziklai Pair based Small Signal Amplifier with BJT-MOSFET Hybrid Unit at 180nm Technology
Rice Straw-Derived Carbon Integrated with PANI: As an Electrode Material for High-performance Supercapacitor
Extraction, Characterisation, Biological Properties and Applications of Essential Oils: A Review
Biopolymeric Materials in the Management of Diabetic Wound Healing: A Comprehensive Review
Entomopathogenic Fungi: Nature

Tags


Recomonded Articles: