Abstract View

Author(s): Sanjay Daharwal, Anju Anant

Email(s): anjuanant4@gmail.com

Address: University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur - 492 010, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Bioavailability is one of the important parameter to achieve desired concentration of drug in systemic circulation. A drug with poor bioavailability is one with poor aqueous solubility, slow dissolution rate in biological fluids, poor stability of dissolved drug at physiological pH, poor permeation through bio membrane, extensive presystemic metabolism. Drugs having low bioavailability require to be administered at a higher dose as only a small fraction of the administered dose is absorbed in the systemic circulation and reach the target site. A various approaches are used for bioavailability enhancement of the orally administered drugs. Insinuation of the novel lipid based nanocarriers and nanomaterials like dendrimers and carbon nanotubes as a delivery system can effectively enhance the oral bioavailability of drugs by breaching the barriers, and resolve all critics related to solubility and bioavailability. Dendrimers have successfully proved themselves as useful additives in different routes of drug administration because they can render drugs greater water solubility, bioavailability, and biocompatibility. These features make it attractive candidates as drug carriers for controlled release or targeted delivery. This review covers the points of synthesis, types, properties, applications, characterisation etc. Poly (amidoamine) (PAMAM) dendrimers with particular reference to oral delivery systems have been evaluated for the influcnce tmanipulate of surface functionality and size on the epithelial barrier of the gut with the goal of identifying safe carriers.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Herbal Alternatives for Oral Health:  Mechanistic Exploration with their Market Potential
Time of the Day Variability in Pit-Building Behavior of Antlion Larvae
A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
Enhanced antioxidant activity in Curcuma caesia Roxb. microrhizomes treated with silver nanoparticles
Studies on the Interaction of Imidazolium Ionic Liquids with Human Serum Albumin
Basic and Advanced Logical Concept Derived from Surface Enhanced Infrared Spectroscopy (SEIRS) as Sensing Probe for Analysis of Chemical Species: A Brief Review
Soil Erosion Risk Estimation by using Semi Empirical RUSLE model: A case study of Maniyari Basin, Chhattisgarh
An Estimator of Population Variance Using Multi-Auxiliary Information
Microemulsion as Novel Drug Delivery for Fungal Eye Infection
Potential of Bioactive Compounds for Atopic Dermatitis

Tags


Recomonded Articles: