Abstract View

Author(s): Sanjay Daharwal, Anju Anant

Email(s): anjuanant4@gmail.com

Address: University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur - 492 010, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016


Bioavailability is one of the important parameter to achieve desired concentration of drug in systemic circulation. A drug with poor bioavailability is one with poor aqueous solubility, slow dissolution rate in biological fluids, poor stability of dissolved drug at physiological pH, poor permeation through bio membrane, extensive presystemic metabolism. Drugs having low bioavailability require to be administered at a higher dose as only a small fraction of the administered dose is absorbed in the systemic circulation and reach the target site. A various approaches are used for bioavailability enhancement of the orally administered drugs. Insinuation of the novel lipid based nanocarriers and nanomaterials like dendrimers and carbon nanotubes as a delivery system can effectively enhance the oral bioavailability of drugs by breaching the barriers, and resolve all critics related to solubility and bioavailability. Dendrimers have successfully proved themselves as useful additives in different routes of drug administration because they can render drugs greater water solubility, bioavailability, and biocompatibility. These features make it attractive candidates as drug carriers for controlled release or targeted delivery. This review covers the points of synthesis, types, properties, applications, characterisation etc. Poly (amidoamine) (PAMAM) dendrimers with particular reference to oral delivery systems have been evaluated for the influcnce tmanipulate of surface functionality and size on the epithelial barrier of the gut with the goal of identifying safe carriers.

Cite this article:
Not Available

References not available.

Related Images:

Recent Images

Chlorpyrifos Mediated Amendment in Protein Profiling of Bacillus spp.
Structural, Compositional and Photoluminescence Studies of Li4SrCa(SiO4)2: Eu3+ Red Phosphor Synthesized by Solid State Reaction Method
Formulation and Characterization of Magnetically Responsive Mesalamine Microspheres for Colon Targeting
Development of Non-Invasive Technique for Heart Rate Detection Using Facial Videos
Human Part Semantic Segmentation Using CDGNET Architecture for Human Activity Recognition
Lifestyle Modification Therapy and its Effect on Weight Status of Non-Alcoholic Male Liver Disease Patients
Exploring Life Cycle Analysis in Developing Sustainable Communities in Chhattisgarh
Monitoring the Concentration of Lead in the Industrial Wastewater of Baloda Bazar District
Impact of Climate Change on Paddy Yield in Bastar District of Chhattisgarh
Chemical Pollutants: A Concern to The Environment


Recomonded Articles: