ABSTRACT:
Development of phytovesicle is a new approach for plant extracts and active components. It is a type of novel drug delivery systems (NDDS). The other available approaches for novel herbal formulations like polymeric nanoparticles, nanocapsules, liposomes, phytosomes, nanoemulsions, microsphere, niosomes, planterosomes, cubosomes, transferosomes, and ethosomes has been reported using bioactive and plant extracts. Many plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, but have less or no in vivo actions due to their poor lipid or water solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine which bind components to each other on a molecular level. Bioavailability is enhanced due to their capacity to cross the lipid rich bio-membranes and to protect the valuable components of the herbal extract from destruction by digestive secretions and gut bacteria. Phytovesicle have the capacity to deliver the standardized plant extracts and phytoconstituents through several routes of drug administration. Phytovesicles absorption in GIT is greater resulting in increased plasma level than individual component. Phytovesicles act as bridge between novel delivery system and conventional delivery system. Phospholipids molecule acting as vital carrier made up of water soluble head and two fat soluble tails, due to this nature they possess dual solubility and thus acting as an effective emulsifier. Phytosome represents a promising vesicular drug delivery system to deliver therapeutic compounds for a wide range of possible applications.
Cite this article:
Gayatree (2016). Development of Phytovesicles of Plant Constituents via Complexation with Phospholipid. Journal of Ravishankar University (Part-B: Science), 29(1), pp.156-157.