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Author(s): PV Khawse, VA Dhande, VD Rangari, SG Gurunani, VD Gulkari, DR Chaple

Email(s): khawsepriti@yahoo.co in

Address: Priyadarshini JL College of Pharmacy, Electronics Zone, MIDC, Hingna Road, Nagpur - 440 016, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No Systematic study has been done on protective efficacy of seeds of capparis zeylanica (Capparidaceae) to treat hepatic diseases. Protective action of Capparis zeylanica seeds methanolic and butanolic extract was evaluated in this study in an animal model of hepatotoxicity, which was induced by carbon tetrachloride. Heathy albino rats (100-150g body weight) were divided into 7 groups. Group 1 was normal control group; group 2, the hapatotoxic group was given CCL: group 3 was administered with standard (Silymarin); group 4-5 received different doses of methanolic extract (200,400 mg/kg) with CCL: Group6-7 was administered dose of the butanolic extract(200-400mg/kg) . The parameters studied were SGPT (Serum glutamic pyruvic transaminase), SGOT (Glutamic-oxalacetic transaminase), and ALP (Alanine Aminotransferase). The hepatoprotective activity was also supported by histopathological study of liver tissue. Results of the biochemical studies of blood samples of CCL, treated animal sbowed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by CCL whereas blood samples from the animals treated with butanolic extract showed significant decrease in the levels of serum markers as compared to the methanolic extract, indicating the protection of hepatic cells. The results revealed that butanolic extract of C. zeylanica could afford significant dose-dependent protection against CCI, induced hepatocellular injury.

Cite this article:
Khawse, Dhande, Rangari, Gurunani, Gulkari and Chaple (2016). Reconnoitering Capparis zeylanica Seeds as Hepatoprotective Agent. Journal of Ravishankar University (Part-B: Science), 29(1), pp.133-134.


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