Free radicals play beneficial as well as damaging role in the living system. In the low or moderate concentration they help in many physiological functions but at high concentration they causes serious oxidative damage of cell structures and cause life threatening disease like cancer. Antioxidants are the substances which neutralize free radicals by donating electrons and prevent damaging effect of free radicals. Plants are the rich source of antioxidant and contain various chemicals which act as antioxidant. Phenolics are important secondary metabolite which exhibit antioxidant activity. In the present study we have studied a correlation between the total phenolic content and antioxidant activity of various solvent from of Clerodendrum serratum L. Clerodendrum setrratum L is an important medicinal plant, which is used in many ayurvedic formulations and exhibit potential antioxidant activity. Four solvent extracts Petroleum ether, chloroform, water and methanol were prepared by hot percolation method. Antioxidant activity and total phenolic content was highest in methanolic extract and least in petroleum ether extract. Data shows strong corelation between antioxidant activity and total phenolic content of various solvent extracts, which support the earlier studies of many workers.
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