Author(s):
Junaid Khan, Swarnlata Saraf, Shailendra Saraf
Email(s):
kallolkghosh@yahoo.com
Address:
Department of Pharmacy, Sarguja University, Ambikapur -497 001, India
University Institute of Pharmacy, P. Ravishankar Shukla University, Raipur 492 010, India.
Published In:
Volume - 29,
Issue - 1,
Year - 2016
DOI:
Not Available
ABSTRACT:
Schleichera oleosa (Sapindaceae) commonly known as 'Koshamra' in Ayurveda is a tropical tree readily found in Asia and is used to treat pain and rheumatism, as traditional medicine in different parts of India. However, scientific evidences to justify these claims are lacking. Considering the traditional use of S.oleosa and the lack of information about its pharmacological properties, we investigated the hepaprotective potential of the alcoholic extract of S.oleosa (SME) against different animal models in rodents. The hepatoprotective activity was evaluated against PCM and GalN/LPS induced hepatic damage. Furthermore, the biochemical mediators like NO (Nitric oxide) and TNF-a were also estimated. The ethanolic extract of S. oleosa bark, did not exhibit any signs of toxicity up to a dose of 2000 mg/kg. The extract significantly reduced the serum level of marker enzymes (p<0.05) indicating its hepatoprotective potential. The histological changes induced by PCM and GalN/LPS were significantly ameliorated by S.oleosa. The response of higher dose of extract was comparable with standard drug silymarin. Histopathological examination of the liver tissues stained with H&E revealed that control groups showed normal histological appearance with structural integrity of hepatic cells without necrosis or inflammation. The results suggest that Soleosa is effective against hepatic damage and its action is markedly influenced by the inhibition of TNF-a and anti-oxidant action.
Cite this article:
Khan, Saraf and Saraf (2016). Hepatoprotective Potential and Possible Mechanism of Schleichera oleosa. Journal of Ravishankar University (Part-B: Science), 29(1), pp.181-182.