Abstract View

Author(s): Taranjeet Kukreja, Swarnlata Saraf

Email(s): swarnlatasaraf@gmail.com

Address: University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur - 492010, Chhattisgarh, India.
University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur - 492010, Chhattisgarh, India.
*Corresponding Author: swarnlatasaraf@gmail.com

Published In:   Volume - 35,      Issue - 2,     Year - 2022

DOI: 10.52228/JRUB.2023-35-2-5  

Itraconazole is a triazole antifungal agent that is synthesised. Itraconazole has been manufactured into a variety of pharmacological formulations and administered in a variety of ways. Itraconazole pills are used to treat pulmonary fungi that can cause fungal infection and spread throughout the body. Because Itraconazole is not yet officially listed in any pharmacopoeia, only a few procedures for quality control and stability testing in pharmaceutical formulations have been published. The goal of this study is to develop a more precise, easy, and cost-effective spectrophotometric approach for analysing Itraconazole in bulk and capsule dosage forms with improved precision, accuracy, and sensitivity. The UV spectroscopic determination was performed with Chloroform as the solvent at an absorption maximum of 267 nm. Linearity over the concentration range in the UV spectroscopic approach. The linearity of Itraconazole over the concentration range was found to be 1-10 g/ml using the UV spectroscopic technique, with a correlation coefficient of 0.999. The findings of the analyses were statistically and the recovery studies have confirmed this.

Cite this article:
Kukreja and Saraf (2022). UV Spectroscopy Analysis for Itraconazole . Journal of Ravishankar University (Part-B: Science), 35(2), pp. 62-67.DOI: https://doi.org/10.52228/JRUB.2023-35-2-5


1.     Khoschsorur G, Frueehwirth F, Zelzer S.Isocratic High-Performance Liquid Chromatographic Method with UV detection for simultaneous determination of voriconazole and itraconazole and its hydroxyl metabolite in human serum. Antimicrobial agents and Chemotherapy, 2005; 49: 3569-3571.

2.     Conway SP, Etherington C, Peckham DG et al. Pharmacokinetics and safety of Itraconazole in patients with cystic fibrosis. Journal of Antimicrobial Chemotherapy,2004; 53: 841-847.

3.     European Pharmacopoeia. Itraconazole, Strasbourg: France, 4thEd, 2005; 1852-1853.

4.     Hay R.J, Dupont B, Graybill J.R. Review Infectious Disease, 1987; 9(Suppl. 1): S1-3

5.     Saag M.S, Dismukes W.E. Antimicrobial Agents Chemotherapy, 1988.

6.      Mechanism of action available online at URL http://www.drugbank.ca/drugs/DB01167.

7.     De Beule K, Van Gestel J. Pharmacology of Itraconazole, 2001; 61(S1): 27–37.

8.      Pharmaceutical applications are available online at URLhttp://www.nlm.nih.gov.

9.      Shalin K. Parikh, Ankit D. Patel, Dr J. B. Dave, Dr C. N. Patel and Dr D. J. Sen, “Development and validation of UV Spectrophotometric method for estimation of itraconazole bulk drug and pharmaceutical formulation” International Journal of Drug Development and Research, 2011; 3(2): 324-328.Stefanie Redmann, Bruce G. Charles, “A rapid HPLC method with fluorometric detection for the determination of plasma itraconazole and hydroxy-itraconazole concentrations in cystic fibrosis children with allergic bronchopulmonary aspergillosis” BiomedicalChromatography, 2006; 20(4): 343–348.

10.  Kramer M, Marshall S, Denning D et al. Cyclosporine and Itraconazole Interaction in Heart and Lung Transplant Recipients. Annals of Internal Medicine, 1990; 113: 327–329.

11.  D. Vijaya Bharathi, Kishore Kumar Hotha, P.V.Vidya Sagar, Sanagapati Sirish Kumar, Pandu Ranga Reddy, A. Naidu, Ramesh Mullangi, “Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of itraconazole and hydroxyitraconazole in human plasma” Science Direct Journal, 2008; 868(1-2): 70-76.

12.  Ming Yao, Laishun Chen, Nuggehally R Srinivas, “Quantitation of itraconazole in rat heparinized plasma by liquid chromatography-mass spectrometry” Journal of Chromatography B: Biomedical Sciences and Applications, 2001; 752(1)5: March 2001;916.

13.  Srivatsan V, Dasgupta A, Kale P, Datla R, Soni D, Patel M, Patel R, and Mavadhiya, C. Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by high-performance liquid chromatography, Journal of Chromatography, 2004; 1031: 307-313.

14.  Zimmermann T, Yeates R.A, Laufen H. European Journal of Clinical Pharmacology, 1994; 46: 147.

15.  Constantinos Kousoulos, Georgia Tsatsou, Constantinos Apostolou, Yannis Dotsikas and Yannis L. Loukas, “Development of a high-throughput method for the determination of itraconazole and its hydroxy metabolite in human plasma, employing automated liquid-liquid extraction based on 96-well format plates and LC/MS/MS ” Analytical and Bioanalytical Chemistry, 2006; 384(1): 199-207.

16.  M. V. Kumudhavalli, “Isocratic RP-HPLC, UV Method Development and Validation Of Itraconazole In Capsule Dosage Form” International Journal of Pharmaceutical Research IJPSR, 2011; 2(12): 3269-3271.

17.   Al-Rawithi H, Sameer M, Hussein A, Rajaa Al-Moshen, Ibrahim, Raines, Dale, et al. Determination of Itraconazole and Hydroxy itraconazole in Plasma by High-Performance Liquid Chromatography with Fluorescence Detection, Therapeutic Drug Monitoring, 2001; 23: 445-448.

18.  El-Enany N, El-Sherbilny D, Belal F. Spectrofluorimetric Determination of Itraconazole in Dosage Forms and Spiked Human Plasma. Journal of the Chinese Chemical Society, 2007; 54: 375-382.

Related Images:

Recent Images

Herbal Alternatives for Oral Health:  Mechanistic Exploration with their Market Potential
Time of the Day Variability in Pit-Building Behavior of Antlion Larvae
A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
Enhanced antioxidant activity in Curcuma caesia Roxb. microrhizomes treated with silver nanoparticles
Studies on the Interaction of Imidazolium Ionic Liquids with Human Serum Albumin
Basic and Advanced Logical Concept Derived from Surface Enhanced Infrared Spectroscopy (SEIRS) as Sensing Probe for Analysis of Chemical Species: A Brief Review
Soil Erosion Risk Estimation by using Semi Empirical RUSLE model: A case study of Maniyari Basin, Chhattisgarh
An Estimator of Population Variance Using Multi-Auxiliary Information
Microemulsion as Novel Drug Delivery for Fungal Eye Infection
Potential of Bioactive Compounds for Atopic Dermatitis


Recomonded Articles:

Author(s): Deepak Kumar Sahu; Joyce Rai; Chhaya Bhatt; Manish K. Rai*; Jyoti Goswami; Ajay Kumar Sahu; Thakur Vikram Singh; Mamta Nirmala; Kalpana Wani and Prashant Mundeja

DOI: 10.52228/JRUB.2018-31-1-1         Access: Open Access Read More

Author(s): Suman Shrivastava, Pooja Deshpande, S. J. Daharwal*

DOI: 10.52228/JRUB.2018-31-1-6         Access: Open Access Read More

Author(s): Pooja Deshpande, Suman Shrivastava, S.J. Daharwal*

DOI: 10.52228/JRUB.2018-31-1-7         Access: Open Access Read More

Author(s): Chhaya Bhatt*; Deepak Kumar Sahua; Thakur Vikram Singh; Kalpana Wani; Jyoti Goswami; Ajay Kumar Sahu; Harshita Sharma; Geetanjali Deshlehre; Manish Kumar Rai*; Joyce Rai.

DOI: 10.52228/JRUB.2020-33-1-2         Access: Open Access Read More

Author(s): Anushree Saha; Manas Kanti Deb*; Mithlesh Mahilang; Shubhra Sinha

DOI: 10.52228/JRUB.2020-33-1-7         Access: Open Access Read More

Author(s): Ajay kumar Sahu; Shraddha Ganesh Pandey; Vindhya Patel; Raisa Khatoon; Mamta Nirmal; Kalpana Wani; Deepak Kumar Sahu; Jyoti Goswami; Chhaya Bhatt; Geetanjali Deshlahare; Harshita Sharma; Manish Kumar Raia* and Joyce Rai

DOI: 10.52228/JRUB.2018-31-1-5         Access: Open Access Read More

Author(s): Harshita Sharma; Anushree Saha; Chhaya Bhatt; Kalpana Wani; Ajay Kumar Sahu; Jyoti Goswami; Arun Kumar Mishra; Manish Kumar Rai*; Joyce Rai

DOI: 10.52228/JRUB.2020-33-1-3         Access: Open Access Read More

Author(s): Jyoti Goswami, Thakur Vikram Singh; Chhaya Bhatt; Deepak Kumar Sahu; Kalpana Wani; Ajay Kumar Sahu; Prashant Mundeja; Manish Kumar Rai*; Joyec Rai

DOI: 10.52228/JRUB.2020-33-1-9         Access: Open Access Read More

Author(s): Ajay Kumar Sahu*; Manish Kumar Rai*; Joyce Rai; Yaman Kumar Sahu; Deepak Kumar Sahu; Kalpana Wani; Jyoti Goswami and Chhaya Bhatt

DOI: 10.52228/JRUB.2021-34-1-12         Access: Open Access Read More

Author(s): Taranjeet Kukreja; Swarnlata Saraf

DOI: 10.52228/JRUB.2023-35-2-5         Access: Open Access Read More

Author(s): Shatabdi Ghose; Umamaheswari S; Susithra E; Rajasekhar Chekkara; Naresh Kandakatla; Uma Maheswara Reddy C

DOI:         Access: Open Access Read More

Author(s): Raisa Khatoon; Prashant Mundeja; Mamta Nirmal; Vindhiya Patel; Kalpana Wani; Ajay Kumar Sahu; Deepak Kumar Sahu; Manish Kumar Rai; Joyce Rai; Pushpy Michael

DOI: 10.52228/JRUB.2017-30-1-6         Access: Open Access Read More

Author(s): Gyanchandra Sahu; RK Pradhan

DOI:         Access: Open Access Read More

Author(s): Meenakshi Thakur; RK Asrani; PK Sharma; RD Patil; Brij Lal; Om Parkash

DOI:         Access: Open Access Read More