Abstract View

Author(s): Anushree Saha, Manas Kanti Deb*, Mithlesh Mahilang, Shubhra Sinha

Email(s): debmanas@yahoo.com

Address: School of Studies in Chemistry, Pt. Ravishankar Shukla University Raipur-492010, Chhattisgarh, India

Published In:   Volume - 33,      Issue - 1,     Year - 2020

DOI: 10.52228/JRUB.2020-33-1-7  

ABSTRACT:
Ion exchange resins (IERs) are solid poly-electrolytes which have both sorption and exchange capacity of several organic compounds. They have the power to separate ionic and non-ionic substances with the surrounding medium. The drug materials or substances are adsorbed on resin, which is commonly known as resinate, these features of IERs have useful applications in pharmaceutical formation (i.e., taste masking, stability & solubility enhancement, etc.) and major applications in drug delivery (i.e., oral, nasal, ophthalmic, transdarmal drug delivery). IE principles have been exploited in the investigation of numerous drug industry problems for many years. Synthetic IERs have been extensively employed in pharmacy and medicine, especially for taste masking or controlled release of drugs and have been expansively studied in the development of novel drug delivery systems and other biomedical applications. In this review, the fascinating IERs involving ion exchange processes in pharmaceutical and clinical applications and also their recent advanced uses have been discussed.

Cite this article:
Saha et al. (2020). Intriguing Clinical and Pharmaceutical Applications of IERs: A Mini Review. Journal of Ravishankar University (Part-B: Science), 33(1), pp. 47-57.DOI: https://doi.org/10.52228/JRUB.2020-33-1-7


Akkaramongkolporn P, Ngawhirunpat T (2003). Dual ambroxal and chlorpheniramine resinate as an alternative carrier in concurrent resinate administration. Die Pharmazie-An Int J Pharm Sci 58(3):195-199.

Akkaramongkolporn P, Terada K, Yonemochi E (2001). Molecular properties of propranolol hydrochloride prepared as drug-resin complexes. Drug Dev Ind Pharm 27(4):359-364.

Alchin D (1998). Ion exchange resin. Chemical process in New Zealand, New Zealand Institute of Chemistry Education, PP XIII-D-1-XIII-D-7.

Alyüz B, Veli S (2009). Kinetics and equilibrium studies for the removal of nickel and zinc from aqueous solutions by ion exchange resin. J Hazard Mater 167(1-3):482-488.

Anand V, Kandarapu R, Garg S (2001). Ion-exchange resins: carrying drug delivery forward. Drug Discov Today 6(17):905-914.

Arnold JD (1986). Belleview Pharmaceutical Inc, Dihydrocodeine/ibuprofen pharmaceutical compositions and method. U.S. Patent 4, 571, 400, 1986.

Agueniou, F., Chebli, D., Reffas, A., Bouguettoucha, A., Benguerba, Y., Favier, L., & Amrane, A. (2018). Impact of TiO2-Cation Exchange Resin Composite on the Removal of Ethyl Violet. Arabian Journal for Science & Engineering (Springer Science & Business Media BV)43(5).

Baraka A, Hall PJ, Heslop MJ (2007). Melamine–formaldehyde–NTA chelating gel resin: Synthesis, characterization and application for copper (II) ion removal from synthetic wastewater. J Hazard Mater 140(1-2):86-94.

Bellamy SA, Hughes L (2003). Rohm and Haas Company, Method for the anhydrous loading of nicotine onto ion exchange resins. U.S. Patent, 6, 607,752, 2003.

Bennett A (2007). High purity water: Advances in ion exchange technology. Filtr Separat 44(6):20-23.

Berge MS, Swarbrick J, Boylan CJ (1996). In Encyclopaedia of Pharamaceutical Technology, Vol 13.

Bhaskar R, Murthy RSR, Miglani BD, Viswanathan K (1986). Novel methods to evaluate diffusion controlled release of drug from resinate. Int J Pharm 28(1):59-66.

Brittain HG, Grant DJ (1999). Effects of polymorphism and solid-state solvation on solubility and dissolution rate. Polymorphism in pharmaceutical solids 95:279-330.

Burke GM, Mendes RW, Jambhekar SS (1986). Investigation of the applicability of ion exchange resins as a sustained release drug delivery system forpropranolol hydrochloride. Drug Dev Ind Pharm 12(5):713-732.

Calmon C (2018). Ion Exchange Pollution Control: Volume II. CRC Press.

Chaubal M.V (2003). Synthetic polymer-based ion exchange resins: excipients & actives. Drug Deliv Technol 3(5).

Chaudhry NC, Saunders L (1956). Sustained release of drugs from ion exchange resins. J Pharm Pharmacol 8(1):975-986.

Cheng YH, Watts P, Hinchcliffe M, Hotchkiss R, Nankervis R, Faraj NF, Smith A, Davis SS, Illum L (2002). Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. J Control Release 79(1-3):243-254.

Cuna M, Jato JV, Torres D (2000). Controlled-release liquid suspensions based on ion-exchange particles entrapped within acrylic microcapsules. Int J Pharm 199(2):151-158.

Chen, X., Sun, S., Wang, X., Wen, J., Wang, Y., Cao, X., ... & Sun, R. (2020). One-pot preparation and characterization of lignin-based cation exchange resin and its utilization in Pb (II) removal. Bioresource Technology, 295, 122297.

Dambies L (2005) Existing and prospective sorption technologies for the removal of arsenic in water. Sep Sci Technol 39(3):603-627.

Dong K, Zeng A, Wang M, Dong Y, Wang K, Guo C, Yan Y, Zhang L, Shi X, Xing J (2016). In vitro and in vivo study of a colon-targeting resin microcapsule loading a novel prodrug, 3, 4, 5-tributyryl shikimic acid. RSC Adv 6(20):16882-16890.

Dyer A, Williams PA (1999). Advances in ion exchange for industry and research. In International Conference on Ion Exchange Processes 1998: North East Wales Institute. RSC.

Das, D., Das, A., & Sinha, C. (1999). A new resin containing benzimidazolylazo group and its use in the separation of heavy metals. Talanta48(5), 1013-1022.

Elder DP (2005). Pharmaceutical applications of ion exchange resinJ Chem Educ 82(4):575-585.

Feng Y, He B, Cao Y, Li J, Liu M, Yan F, Liang X (2010). Biodiesel production using cation-exchange resin as heterogeneous catalyst. Bioresour Technol 101(5):1518-1521.

Fisher S, Kunin R (1955). Routine exchange capacity determinations of ion exchange resins. Anal chem 27(7):1191-1194.

Fu F, Wang Q (2011). Removal of heavy metal ions from wastewaters: a review. J Environ Manage 92(3):407-418.

Gill RJ, Duncan GG, Hunscher MA (1952). Arterial Hypertension—The Therapeutic Effect of Cation-Exchange Resins. N Engl J Med247(8):271-276.

Greenleaf JE, Lin JC, Sengupta AK (2006). Two novel applications of ion exchange fibers: Arsenic removal and chemical‐free softening of hard water. Environ Prog Sustain Energy 25(4):300-311.

Greenman L, Shaler JB, Danowski TS (1953). Biochemical disturbances and clinical symptoms during prolonged exchange resin therapy in congestive heart failure. Am J Med 14(4):391-403.

Hänninen K, Kaukonen AM, Kankkunen T, Hirvonen J (2003). Rate and extent of ion-exchange process: the effect of physico-chemical characteristics of salicylate anions. J Control Release 91(3):449-463.

Higaki M, Takase T, Igarashi R, Suzuki Y, Aizawa C, Mizushima Y (1998). Enhancement of immune response to intranasal influenza HA vaccine by microparticle resin. Vaccine 16(7):741-745.

Hughes L (2005). Ion Exchange Resinates. Pharmaceutical Technology Europe 17(4):38-42.

Hughes L, Gehris A (2003). A new method of characterizing the buccal dissolution of drugs. Spring House: Rohm and Haas Research Laboratories.

Haddad, M., Oie, C., Duy, S. V., Sauvé, S., & Barbeau, B. (2019). Adsorption of micropollutants present in surface waters onto polymeric resins: Impact of resin type and water matrix on performance. Science of The Total Environment, 660, 1449-1458.

Ichikawa H, Fujioka K, Adeyeye MC, Fukumori Y (2001). Use of ion-exchange resins to prepare 100 μm-sized microcapsules with prolonged drug-release by the Wurster process. Int J Pharm 216(1-2):67-76.

Illum L (1999). Danbiosyst UK Ltd, Nasal drug delivery composition containing nicotine. U.S. Patent 5,935,604, 1999.

Irwin WJ, Belaid KA (1987). Drug-delivery by ion-exchange. Part I: ester pro-drugs of propranolol. Drug Dev Ind Pharm 13(9-11):2017-2031.

Irwin WJ, MacHale R, Watts PJ (1990). Drug-delivery by ion-exchnage. Part VII: Release of acidic drugs from anionic exchange resinate complexes. Drug Dev Ind Pharm 16(6):883-898.

Irwin WJ (1974). Vitro binding of drugs to Colestipol hydrochloride, J. Pharm. Sci., 63:1914-1920.

Jana S, Ghosh SK, Nath S, Pande S, Praharaj S, Panigrahi S, Basu S, Endo T, Pal T (2006). Synthesis of silver nanoshell-coated cationic polystyrene beads: A solid phase catalyst for the reduction of 4-nitrophenol. Appl Catal A Gen 313(1):41-48.

Jani R, Gan O, Ali Y, Rodstrom R, Hancock S (1994) Ion exchange resins for ophthalmic delivery. J Ocul Pharmacol Ther 10(1):57-67.

Jeong SH, Park K (2008). Development of sustained release fast-disintegrating tablets using various polymer-coated ion-exchange resin complexes. Int J Pharm 353(1-2):195-204.

Junyaprasert VB, Manwiwattanakul G (2008). Release profile comparison and stability of diltiazem–resin microcapsules in sustained release suspensions. Int J Pharm 352(1-2):81-91.

Jia, Y., Ding, L., Ren, P., Zhong, M., Ma, J., & Fan, X. (2020). Performances and Mechanism of Methyl Orange and Congo Red Adsorbed on the Magnetic Ion-Exchange Resin. Journal of Chemical & Engineering Data, 65(2), 725-736.

Kang SY, Lee JU, Moon SH, Kim KW (2004). Competitive adsorption characteristics of Co2+, Ni2+, and Cr3+ by IRN-77 cation exchange resin in synthesized wastewater. Chemosphere 56(2):141-147.

Kanios D (2002). Compositions and methods to affect the release profile in the transdermal administration of active agents. U.S. Patent Application 09/765,932, 2002.

Kankkunen T, Huupponen I, Lahtinen K, Sundell M, Ekman K, Kontturi K, Hirvonen J (2002). Improved stability and release control of levodopa and metaraminol using ion-exchange fibers and transdermal iontophoresis. Eur J Pharm Sci 16(4-5):273-280.

Kasture AV, Mahadik KR, Wadodkar SG, More HN (2002). Pharmaceutical analysis, Volume-II, Nirali prakashan. 8th edition, 43.

Kichener JA (1957). Ion Exchange Resins, New York: John Wiley & Sons.

Klasovsky F, Hohmeyer J, Bruckner A, Bonifer M, Arras J, Steffan M, Lucas M, Radnik J, Roth C, Claus P (2008). Catalytic and Mechanistic Investigation of Polyaniline Supported PtO2 Nanoparticles: A Combined in situ/operando EPR, DRIFTS, and EXAFS Study. J Phys Chem C 112(49):19555-19559.

Kouchak M, Ramezani Z, Bagheri F (2018). Preparation and evaluation of taste masking iron suspension: taking advantage of weak cationic exchange resin. AAPS Pharm Sci Tech 19(2):719-729.

Kunin R (1958). Ion Exchange Resins, New York: John Wiley & Sons.

Lu MYF, Borodkin S, Woodward L, Li P, Diesner C, Hernandez L, Vadnere M (1991). A polymer carrier system for taste masking of macrolide antibiotics. Pharm Res 8(6):706-712.

Mahore JG, Wadher KJ, Umekar MJ, Bhoyar PK  (2010). Ion exchange resins: pharmaceutical applications and recent advancement. Int J Pharm Sci Rev Res 1(2):8-13.

Malik MA, Ali SW, Ahmed I (2010). Sulfonated Styrene− Divinybenzene Resins: Optimizing Synthesis and Estimating Characteristics of the Base Copolymers and the Resins. Ind Eng Chem Res 49(6):2608-2612.

Manek SP, Kamat VS (1981). Evaluation of Indion CRP-244 and CRP-254 as sustained release and taste masking agents. Indian J Pharm Sci43(11-12):209-212.

Mehndal SN, Malshe VC (1991). Eastern Pharmacist 3.

Meidar D (1978). Heterogenous Catalysis by Solid Superacids; 101. Mercury Impregnated Nafion-H Perfluorinated Resinsulfonic Acid Catalyzed Hydration of Alkynes. Synthesis 1978(09):671-672.

Mizushima Y, Kosaka Y, Hosokawa K, Nagata R, Higaki M, Igarashi R, Ebata T (1999) LTT Institute Co Ltd, Medicaments for nasal administration. U.S. Patent 5, 942,242.

Mori K, Dojo M, Yamashita H (2013). Pd and Pd–Ag nanoparticles within a macroreticular basic resin: an efficient catalyst for hydrogen production from formic acid decomposition. ACS Catal 3(6):1114-1119.

Payne WW (1956). Ion exchange resins in clinical medicine. J Pharm Pharmacol 8(1):397-402.

Pisal S, Zainnuddin R, Nalawade P, Mahadik K, Kadam S (2004) Drug release properties of polyethylene-glycol-treated ciprofloxacin-Indion 234 complexes. AAPS Pharm Sci Tech 5(4):101-106.

Pisal S, Zainnuddin R, Nalawade P, Mahadik K, Kadam S (2004) Molecular properties of ciprofloxacin-Indion 234 complexes. AAPS Pharm Sci Tech 5(4):84-91.

Plaizier-Vercammen JA (1992). Investigation of the bioavailability of codeine from a cation ion-exchange sulfonic acid: 1. Effect of parameters. Int J Pharm 85(1-3):45-50.

Praharaj S, Nath S, Ghosh SK, Kundu S, Pal T (2004). Immobilization and recovery of Au nanoparticles from anion exchange resin: resin-bound nanoparticle matrix as a catalyst for the reduction of 4-nitrophenol. Langmuir 20(23):9889-9892.

Raghunathan Y, Amsel L, Hinsvark O, Bryant W (1981). Sustained‐release drug delivery system I: Coated ion‐exchange resin system for phenylpropanolamine and other drugs. J Pharm Sci 70(4):379-384.

Roy GLENN (1997). General ingredient or process approaches to bitterness inhibition and reduction in oral pharmaceuticals. Modifying Bitterness: Mechanisms, Ingredients and Applications. Lancaster, PA: Technomic Publishing 285-320.

Saari P, Heikkila H, Hurme M (2010). Adsorption equilibria of arabinose, fructose, galactose, glucose, mannose, rhamnose, sucrose, and xylose on ion-exchange resins. Chem Eng Data 55(9):3462-3467.

Sharma YC, Singh B, Korstad J (2011). Advancements in solid acid catalysts for ecofriendly and economically viable synthesis of biodiesel. Biofuel Bioprod Biorefin 5(1):69-92.

Shibasaki-Kitakawa N, Tsuji T, Chida K, Kubo M, Yonemoto T (2010). Simple continuous production process of biodiesel fuel from oil with high content of free fatty acid using ion-exchange resin catalysts. Energy & Fuels 24(6):3634-3638.

Siegel S (1962). Stabilization of Cold Tablets. J Pharm Sci 51:1069.

Simon G (1991). Ion Exchange Training Manual, New York: Van Nostrand Reinhold.

Sohi H, Sultana Y, Khar RK (2004). Taste masking technologies in oral pharmaceuticals: recent developments and approaches. Drug Dev Ind Pharm 30(5):429-448.

Sole KC, Mooiman MB, Hardwick E (2018). Ion exchange in hydrometallurgical processing: an overview and selected applications. Sep Purif Rev 47(2):159-178.

Srikanth MV, Sunil SA, Rao NS, Uhumwangho MU, Murthy KR (2010). Ion-exchange resins as controlled drug delivery carriers. Int J Sci Res 2(3):597-611.

Sriwongjanya M, Bodmeier R (1998). Effect of ion exchange resins on the drug release from matrix tablets. Eur J Pharm Biopharm 46(3):321-327.

Ulviya S, Amrita BN (2000). Oral controlled release bromhexine-ion exchange resinate suspension formulation. Indian Drugs-Bombay 37(4):185-189.

Van Abbe NJ, Rees JT (1998). An approach for development of oral sustained release suspension. J Am Pharm Assoc 47:487.

Van Rheenen PR (2004). Rohm and Haas Company, Coating Composition Containing Ion Exchange Resins. U.S. Patent 6, 815,466.

Vincent C, Warfield RB (1963). Bristol-Myers Co, Tablet Disintegrants. U.S. Patent 3, 091,574.

Xing Y, Chen X, Wang D (2007). Electrically regenerated ion exchange for removal and recovery of Cr (VI) from wastewater. Environ Sci Technol 41(4):1439-1443.

Yu L, Li S, Yuan Y, Dai Y, Liu H (2006). The delivery of ketoprofen from a system containing ion-exchange fibers. Int J Pharm 319(1-2):107-113.

Related Images:



Recent Images



Performance Evaluation of Spectrogram Based Epilepsy Detection Techniques Using Gray Scale Features
Perovskite Solar Cells an Efficient, Low Cost, Emerging Photovoltaic Technology
Spectrophotometric Determination of Phenthoate in Vegetables and Fruit Samples of Kabirdham (Chhattisgarh)
Flotation-Dissolution-Spectrophotometric Determination of Phorate in Various Environmental Samples
Preparation, Fabrication and Characterization of Sol-Gel ZnO Thin Films for Organic Solar Cells
Distribution of Some Selected Surface Active Agents (SAAs) in the Aquatic and Global Environment with Their Toxic Impact: A Comprehensive Review
Intriguing Clinical and Pharmaceutical Applications of IERs: A Mini Review
Soil Contamination in the Industrial Vicinity of Bemetara and Raipur District of Chhattisgarh, India
An Extractive Spectrophotometric Method for the Determination of Pymetrozine in Various Ecological Samples of Bilaspur District (C.G.)
Development and Characterization of Quercetin Loaded Nanoparticle for Skin Cancer

Tags


Recomonded Articles:

Author(s): Suman Shrivastava, Pooja Deshpande, S. J. Daharwal*

DOI: 10.52228/JRUB.2018-31-1-6         Access: Open Access Read More

Author(s): Anushree Saha; Manas Kanti Deb*; Mithlesh Mahilang; Shubhra Sinha

DOI: 10.52228/JRUB.2020-33-1-7         Access: Open Access Read More

Author(s): D Khokhar; S Patel; NK Mishra; PS Pisalkar; AK Geda

DOI:         Access: Open Access Read More

Author(s): JK Nandagawe; PK Patil; RD Lawangar-Pawer

DOI:         Access: Open Access Read More

Author(s): Subhalakshmi Ghosh; Banasri Hazra

DOI:         Access: Open Access Read More

Author(s): Swarnlata Saraf; Shailendra Saraf

DOI:         Access: Open Access Read More

Author(s): Rajib Bandyopadhyay

DOI:         Access: Open Access Read More

Author(s): Prasad A Wadegaonkar

DOI:         Access: Open Access Read More

Author(s): B S Ajitkumar; Prashant S Hande; Vikas Jha; Pratiksha Alagh; Shailendra Rane

DOI:         Access: Open Access Read More

Author(s): Shweta Sao; Hemlata Nishad

DOI:         Access: Open Access Read More

Author(s): Chanchal Deep Kaur

DOI:         Access: Open Access Read More

Author(s): Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Renu Bhatt; Neha Pandey

DOI:         Access: Open Access Read More

Author(s): Deepika Mahobiya; A.K. Gupta

DOI:         Access: Open Access Read More