Abstract View

Author(s): Thiyagarajan Sivaprakasam, Sandeep Ravi Varma, Ilavarasu Arumugam, Sunil Prabhu, Rangesh P

Email(s): thiyagarajan.os@himalayawelness.com

Address: Research and Development Centre, The Himalaya Drug Company, Makali, Bangalore - 562 162, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Virgin coconut oil (VCO) has been traditionally used as moisturizer since centuries by people in the tropical region. Clinical studies have revealed that VCO improves the symptoms of skin disorders by moisturizing and soothing the skin. However, the mechanistic action of VCO and its benefits on skin has not been elucidated in vitro. The cytotoxicity (CTC) of VCO was tested in both THP-1 (Human monocytes) and HaCaT (Human keratinocytes) cells. The anti- inflammatory activity of VCO was tested with pro inflammatory cytokines TNF-a, IFN-y, IL-6, IL-8 and IL-5 by ELISA and semi-quantitative RT-PCR. The effect of VCO on aquaporin-3 (AQP3), involucrin (IVL), and filaggrin (FLG) was measured by ELISA and semi-quantitative RT- PCR respectively. The cytokines were down regulated in THP-1 cells and increased gene expression was observed for AQP3, IVL, and FLG in HaCaT cells, post treatment with VCO. The present study demonstrated the inhibitory role of VCO on inflammatory mediators that suggest its beneficial roles in suppressing inflammation associated with skin disorders and maintaining skin barrier function by enhancing gene expression of AQP3, IVL, and FLG. This study is the first to report the anti-inflammatory and skin protective benefits of VCO in vitro.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Chlorpyrifos Mediated Amendment in Protein Profiling of Bacillus spp.
Structural, Compositional and Photoluminescence Studies of Li4SrCa(SiO4)2: Eu3+ Red Phosphor Synthesized by Solid State Reaction Method
Formulation and Characterization of Magnetically Responsive Mesalamine Microspheres for Colon Targeting
Development of Non-Invasive Technique for Heart Rate Detection Using Facial Videos
Human Part Semantic Segmentation Using CDGNET Architecture for Human Activity Recognition
Lifestyle Modification Therapy and its Effect on Weight Status of Non-Alcoholic Male Liver Disease Patients
Exploring Life Cycle Analysis in Developing Sustainable Communities in Chhattisgarh
Monitoring the Concentration of Lead in the Industrial Wastewater of Baloda Bazar District
Impact of Climate Change on Paddy Yield in Bastar District of Chhattisgarh
Chemical Pollutants: A Concern to The Environment

Tags


Recomonded Articles: