M N Motiwala, R A Gupta, N G Dumore, U N Mahajan, K R Danao
Assistant Professor, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra.
Volume - 29,
Issue - 1,
Year - 2016
The leaves of Coccinia indica has been traditionally used by Indian village people in wound healing, jaundice, hypocholestrolemia and inflammation. The phytoconstituents of C. indica includes flavonoids and stilbenes. Wound healing is a complex process that includes inflammation, tissue formation, and remodeling. In order to scientifically prove the claimed utilization of the plant, the effects of the extracts were investigated using burn wound model in mice including in vivo antioxidant and antimicrobial activity. Healing was assessed by the rate of wound contraction, period of epithelization and hydroxyproline content. The antimicrobial activity of extract was also studied against bacterial and fungal strain using agar dilution method. In vivo antioxidant activity was performed to understand the mechanism of wound healing potency The result showed that C. indica leaf extract has significant wound healing activity as evident from the rate of wound contraction and epithelization. Hydroxyproline content was correlative with the healing pattern observed. C. indica leaf extract treatment promotes TLR-4 mediated upregulation of proinflammatory cytokines tnf-a during early phase of wound healing, inhibit ROS accumulation and exhibit moderate antimicrobial activity. We propose induction of cytokine production as one of the mechanism for acceleration of wound healing by Cindica leaf extract which may be due to flavonoids and stilbenes.
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Cite this article:
Motiwala, Gupta, Dumore, Mahajan and Danao (2016). TLR-4 Mediated Wound Healing Activity of Coccinia indica on Burn Wound Model in Mice. Journal of Ravishankar University (Part-B: Science), 29(1), pp.106-107.