Diabetic patients increase their body's vulnerability to contamination and diabetes is a risk factor for impediments and infection. Though various studies showed the mechanism of impaired healing in diabetes and there are still arguments to provide information on factors, comprising local and systemic factors are interwoven in the extended wound healing. We focus on the pathophysiology of healing procedure with specific consideration to the pathophysiology of diabetic wounds and review the reports on the healing process in diabetes and various approaches for management of diabetic wounds. Delayed vascularisation, reduce blood flow, immunity deficiency, reduce growth factor production, various psychological stresses and factors may be involved in the impaired wound healing. The standard treatment of diabetic wound includes glycaemic control as well as debridement, limit infection by antibiotic therapy based on pathogen cultures, the use of natural moist dressings scaffold, and offloading the pressure from the diabetic wounds.
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