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Author(s): Ruchika Chandrakar, Amber Vyas, Narendra Kumar, Umakant Sahu, Vishal Jain

Email(s): vishaljain123@gmail.com

Address: University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G), India-492010
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G), India-492010
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G), India-492010
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G), India-492010
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G), India-492010
*Corresponding author:vishaljain123@gmail.com

Published In:   Volume - 37,      Issue - 2,     Year - 2024

DOI: 10.52228/JRUB.2024-37-2-8  

ABSTRACT:
The medicinal potential of phytoconstituents obtained from plants is widely recognized. Whole-plant extracts or isolated phytoconstituents have been shown through experiments to exhibit a variety of medicinal potentials, including antibacterial, neurologically protective, liver-protective properties, an antioxidant and skin-protective properties. Although these phytoconstituents offer potential therapeutic effects, their usage is restricted due to inadequate bioavailability, persistence in physiological fluids, and authenticity problems. These remain unresolved issues that impact the use of these priceless traditional herbal remedies in the efficient management and treatment of a range of medical ailments. Phytoconstituents’ loading in phospholipid-based vesicular systems may be a way to tackle these challenging issues. The goal of this review is to summarize phyto-phospholipid vesicles and some of their relevant uses in drug delivery systems, as well as to emphasize the relationship between properties and applications, as well as the effect of phospholipid species on drug delivery efficiency. Based on the findings of various research investigations, this literature review attempts to investigate why Phyto-phospholipid vesicles are considered as the best nanotechnology in delivery systems for drugs. Optimal absorption and utilization of nutraceuticals and herbal medications can be enhanced by the process of Phyto phospholipid complexation.

Cite this article:
Chandrakar, Vyas, Kumar, Sahu and Jain (2024). Phyto-phospholipid Complex Vesicles:A Revolutionary Approach for Enhancing Bioavailability and Optimizing Therapeutic Potential in Herbal Medicine. Journal of Ravishankar University (Part-B: Science), 37(2), pp. 80-95. DOI:DOI: https://doi.org/10.52228/JRUB.2024-37-2-8


References:

Agarwal, A., Wahajuddin, M., Chaturvedi, S., Singh, S. K., Rashid, M., Garg, R Chauhan, DSultana, N., Gayen, J. R. (2024). Formulation and Characterization of Phytosomes as Drug Delivery System of Formononetin: An Effective Anti-Osteoporotic Agent. Current Drug Delivery, 21(2): 261-270.

Allaw, M., Manca, M. L., Castangia, I. and Manconi, M. (2022). From plants to phospholipid vesicles: A comprehensive review on the incorporation of phytochemicals into phospholipid vesicles designed for skin applications with special focus on scalability and in vitro and in vivo efficacy. Journal of Drug Delivery Science and Technology, 67: 103049.

Amjadi, S., Shahnaz, F., Shokouhi, B., Azarmi, Y., Siahi-Shadbad, M., Ghanbarzadeh, S., ... & Hamishehkar, H. (2021). Nanophytosomes for enhancement of rutin efficacy in oral administration for diabetes treatment in streptozotocin-induced diabetic rats. International journal of pharmaceutics, 610: 121208..

Andishmand, H., Yousefi, M., Jafari, N., Azadmard-Damirchi, S., Homayouni-Rad, A., Torbati, M. and  Hamishehkar, H. (2024). Designing and fabrication of colloidal nano-phytosomes with gamma-oryzanol and phosphatidylcholine for encapsulation and delivery of polyphenol-rich extract from pomegranate peel. International Journal of Biological Macromolecules, 256: 128501.

 

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