Carissa spinarum is medicinal plants which are used in treatment of rheumatism, purgative and snake repellent in India traditionally. 43 million people about 20 percent of population in United State are suffering from inflammatory diseases. This number will be expected to 60 million by 2020. It is a disease which is caused by physical trauma, harmful chemicals and some microbiological agents. Some symptoms of inflammation are redness, swelling, pain, heat and weakness. Present study was undertaken to investigate phytoconstituents and antiinflammatory activity of the C. spinarum leave extract. Powdered C. spinarum leaves were extracted by using soxhlet apparatus with petroleum ether, chloroform, ethanol and distilled water separately. Formalin induced rat hind paw edema method was used for analysing pharmacological activity. Group was divided into seven groups; Group I normal control, Group II formalin control, Group III standard drug, Group IV, V, VI and VII are test groups. Analgin was taken as standard drug. 200mg/kg petroleum ether extract, chloroform extract, ethanol extract and aqueous extract of C spinarum leaves were feed to group IV, V, VI and VII respectively. All test groups were shown significant antiinflammatory activity. Aqueous group was exhibited maximum antiinflammatory activity in compare to other test groups. Antiinflammatory activity of plant is may be due to presence of some phytoconstituents such as alkaloids, steroids, tannins, carbohydrates and lipids. In conclusion C. spinarum is having potent anti-inflammatory activity.
Cite this article:
Beck and Namdeo (2016). Investigation on Preliminary Phytoconstituents Screening and Antiinflammatory Activity of Carissa spinarum. Journal of Ravishankar University (Part-B: Science), 29(1), pp.194-195.