ABSTRACT:
Diabetes is a disease of altered glucose homeostasis and persistent hyperglycemia leading to advanced glycation end product (AGE) which are primarily responsible for the damage of cells which have a slow turn over (like neuronal tissue). This abnormality results in poor wound healing. Further hyperglycemic complication leads to wound infection. Wound management is a significant and growing health burden on the community. In the Indian context, the formal descriptions of wound care have been vividly elaborated in the three great treatises (Brahatrayi) of Ayurveda viz. Charaka Samhita, Sushruta Samhita and Astanga Sangraha. Some of the herbal drugs with proven antidibetic and wound healing activity are Jaati (Jasminum officinale linn), Neem (Azadirachta indica AJuss), Patol (Trichiosanthes dioica. Rozb) and Haridra (Curcuma longa linn.). The present work is aimed to standardize and to evaluate the diabetic wound healing activity of polyherbal formulation, JAATYADI GHRITA contain these herbs. The work also includes Evaluation of Physicochemical Parameters, Phytochemical screening, and Quantitative estimation of identified phytoconstituents using HPTLC & HPLC analysis and in-vitro antimicrobial studies. This will act as a referential source of information for researchers who have interest in the relevant field.