ABSTRACT:
Diabetes is a chronic metabolic disease associated with severe complications. Despite of progress in medicinal industry herbal medicines are preferred due to their reducing side effects. Hedychiumcoronarium member of zingiberaceae family has been reported as a medicine for various diseases. The present study was undertaken to isolate and characterize the compounds from the extract of rhizome of H.coronarium and to evaluate their efficacy on in-vitro models of type-Il diabetes. Isolation of compounds from the active dichloromethane (DCM) and ethyl acetate (EA) extract of rhizome of H.coronarium was achieved by Silica gel column chromatography to yield different fractions. The bioactive fractions were then subjected to further purification to obtain purificd compounds. The antidiabetic properties of the compounds were evaluated in-vitro by a- amylase and a- glucosidase enzyme assay. The isolated terpenes from the fractions exhibited inhibition against a- amylase and a- glucosidase in in-vitro correlating to reduce the plasma glucose level. The present investigation suggests the use of the isolated terpenes for treatment of type-ll diabetes in future to reduce the side effects of marketed drugs.
Cite this article:
Panigrahy and Bhatt (2016). Target Guided Isolation and In-Vitro Antidiabetic Activity of Compounds Isolated from Hedychium coronarium Rhizome. Journal of Ravishankar University (Part-B: Science), 29(1), pp.104-105.