Abstract View

Author(s): Ranjit K Harwansh, Pulok K Mukherje, Rajarshi Biswas, Sayan Biswas, Shiv Bahadur

Email(s): harwanshranjeer@gmail.com

Address: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
The study was aimed to develop a genistien (GN) loaded nanoemulsion based nano-gel in order to ensure increased photo-protection efficacy against UVA induced oxidative stress and its enhanced bioavailability through transdermal delivery. The optimized GN-NE2 composed of an appropriate ratio (15:30.55 % w/w) of the oil (labrafac Lipophile WL1349), water and Smix (surfactant (labrasol) and co-surfactant (PEG 400)] respectively. GN-NE2 was characterized by through droplet size, zeta potential, refractive index, TEM, UV and FTIR analysis. Ex vivo skin permeation and in vivo UVA protection activity of GN-NE2 based nano-gels (GN-NG2) along with placebo-NG were studied through the rat skin. The pharkacokinetics and bioavailability of pure GN and its nano-gel, GN-NG2 was studied at dose of 20 mg/kg in rats. GN-NG2 exhibited enhanced UVA protection efficacy and antioxidant potential due to its improved pharmacokinetics (Cmat: 95.06 z 4.09 ngml"; tuzel: 3.81 2 0.25 h) and % relative bioavailability (352.58) when compared to pure GN. Nano- gel significantly ('P < 0.01) released the drug in a sustained manner to maintain the minimum effective concentration for extended period of times. Nano-gel could elevate the level of skin marker enzymes against oxidative stress mediated by UVA. Thus, transdermal route of nano-gel of GN offers an effective strategy for enhancing their bioavailability.

Cite this article:
Harwansh, Mukherje, Biswas, Biswas and Bahadur (2016). Nanoemulsion Based Nano-Gel ofr Genistien Enhancing UVA Protection Efficacy and Bioavailability by Improving its Pharmacokinetics through Transdermal Delivery. Journal of Ravishankar University (Part-B: Science), 29(1), pp.88-89.


References not available.

Related Images:



Recent Images



Potential of Bioactive Compounds for Atopic Dermatitis
Time-Frequency Image-based Speech Emotion Recognition using Artificial Neural Network
Zn Fortification Influential Impact on the Productivity of Calocybe indica Mycelium
Enhanced ACO in clustering algorithm for QoS in WSN enabled IoT
A Modified Regression Type Estimator Using Two Auxiliary Variables
Sziklai Pair based Small Signal Amplifier with BJT-MOSFET Hybrid Unit at 180nm Technology
Rice Straw-Derived Carbon Integrated with PANI: As an Electrode Material for High-performance Supercapacitor
Extraction, Characterisation, Biological Properties and Applications of Essential Oils: A Review
Biopolymeric Materials in the Management of Diabetic Wound Healing: A Comprehensive Review
Entomopathogenic Fungi: Nature

Tags


Recomonded Articles:

Author(s): Deepali Nagre; Roseline Xalxo; Vibhuti Chandrakar; S. Keshavkant

DOI: DOI: 10.52228/JRUB.2021-34-1-10         Access: Open Access Read More

Author(s): Rupal Purena; Renu Bhatt

DOI:         Access: Open Access Read More

Author(s): Richa Shri; Kundan Singh Bora; Abhishek Bhanot; Rahul Kumar; Amit Kumar

DOI:         Access: Open Access Read More

Author(s): Mahesh Kumar Kharat; Milind Patole; Kalpana Pai

DOI:         Access: Open Access Read More

Author(s): Manmohan S Jangdey; Anshita Gupta; Shailendra Saraf; Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Akanksha Jain; Pradeep Kumar Naik; Sunil Kumar Senapati

DOI:         Access: Open Access Read More

Author(s): Sanjay Kumar Chelak; Shailendra Saraf

DOI:         Access: Open Access Read More

Author(s): PA Dharammali; V Mangrulkar; SA Deshpande; AJ Chourasia; DR Chaple

DOI:         Access: Open Access Read More

Author(s): Sanjay Daharwal; Anju Anant

DOI:         Access: Open Access Read More

Author(s): Shikha Srivastava; Manju R Singh; Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Gunjan Jeswani; Ajazuddin

DOI:         Access: Open Access Read More

Author(s): Ranjit K Harwansh; Pulok K Mukherje; Rajarshi Biswas; Sayan Biswas; Shiv Bahadur

DOI:         Access: Open Access Read More