Abstract View

Author(s): Ranjit K Harwansh, Pulok K Mukherje, Rajarshi Biswas, Sayan Biswas, Shiv Bahadur

Email(s): harwanshranjeer@gmail.com

Address: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
The study was aimed to develop a genistien (GN) loaded nanoemulsion based nano-gel in order to ensure increased photo-protection efficacy against UVA induced oxidative stress and its enhanced bioavailability through transdermal delivery. The optimized GN-NE2 composed of an appropriate ratio (15:30.55 % w/w) of the oil (labrafac Lipophile WL1349), water and Smix (surfactant (labrasol) and co-surfactant (PEG 400)] respectively. GN-NE2 was characterized by through droplet size, zeta potential, refractive index, TEM, UV and FTIR analysis. Ex vivo skin permeation and in vivo UVA protection activity of GN-NE2 based nano-gels (GN-NG2) along with placebo-NG were studied through the rat skin. The pharkacokinetics and bioavailability of pure GN and its nano-gel, GN-NG2 was studied at dose of 20 mg/kg in rats. GN-NG2 exhibited enhanced UVA protection efficacy and antioxidant potential due to its improved pharmacokinetics (Cmat: 95.06 z 4.09 ngml"; tuzel: 3.81 2 0.25 h) and % relative bioavailability (352.58) when compared to pure GN. Nano- gel significantly ('P < 0.01) released the drug in a sustained manner to maintain the minimum effective concentration for extended period of times. Nano-gel could elevate the level of skin marker enzymes against oxidative stress mediated by UVA. Thus, transdermal route of nano-gel of GN offers an effective strategy for enhancing their bioavailability.

Cite this article:
Harwansh, Mukherje, Biswas, Biswas and Bahadur (2016). Nanoemulsion Based Nano-Gel ofr Genistien Enhancing UVA Protection Efficacy and Bioavailability by Improving its Pharmacokinetics through Transdermal Delivery. Journal of Ravishankar University (Part-B: Science), 29(1), pp.88-89.


References not available.

Related Images:



Recent Images



Herbal Alternatives for Oral Health:  Mechanistic Exploration with their Market Potential
A Review on Extraction, Identification and Application of Pesticidal Active Phytoderived Metabolites
Determination of Total Dissolved Solids (TDS) of RO Purified Drinking Water Samples in Raipur
Time of the Day Variability in Pit-Building Behavior of Antlion Larvae
A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
Enhanced antioxidant activity in Curcuma caesia Roxb. microrhizomes treated with silver nanoparticles
Studies on the Interaction of Imidazolium Ionic Liquids with Human Serum Albumin
Basic and Advanced Logical Concept Derived from Surface Enhanced Infrared Spectroscopy (SEIRS) as Sensing Probe for Analysis of Chemical Species: A Brief Review
Soil Erosion Risk Estimation by using Semi Empirical RUSLE model: A case study of Maniyari Basin, Chhattisgarh
An Estimator of Population Variance Using Multi-Auxiliary Information

Tags


Recomonded Articles:

Author(s): Deepali Nagre; Roseline Xalxo; Vibhuti Chandrakar; S. Keshavkant

DOI: DOI: 10.52228/JRUB.2021-34-1-10         Access: Open Access Read More

Author(s): Rupal Purena; Renu Bhatt

DOI:         Access: Open Access Read More

Author(s): Richa Shri; Kundan Singh Bora; Abhishek Bhanot; Rahul Kumar; Amit Kumar

DOI:         Access: Open Access Read More

Author(s): Manmohan S Jangdey; Anshita Gupta; Shailendra Saraf; Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): Mahesh Kumar Kharat; Milind Patole; Kalpana Pai

DOI:         Access: Open Access Read More

Author(s): Akanksha Jain; Pradeep Kumar Naik; Sunil Kumar Senapati

DOI:         Access: Open Access Read More

Author(s): Sanjay Kumar Chelak; Shailendra Saraf

DOI:         Access: Open Access Read More

Author(s): PA Dharammali; V Mangrulkar; SA Deshpande; AJ Chourasia; DR Chaple

DOI:         Access: Open Access Read More

Author(s): Sanjay Daharwal; Anju Anant

DOI:         Access: Open Access Read More

Author(s): Shikha Srivastava; Manju R Singh; Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Gunjan Jeswani; Ajazuddin

DOI:         Access: Open Access Read More

Author(s): Amit Alexander; Ajazuddin

DOI:         Access: Open Access Read More

Author(s): Ranjit K Harwansh; Pulok K Mukherje; Rajarshi Biswas; Sayan Biswas; Shiv Bahadur

DOI:         Access: Open Access Read More