Abstract View

Author(s): Mahesh Kumar Kharat, Milind Patole, Kalpana Pai

Email(s): kalpanapai@wnipune.ac.in

Address: Department of Zoology, Savitribai Phule Pune University, Ganeshkhind, Pune - 411 007, Maharashtra, India
National Centre for Cell Science, NCCCS Complex, University of Pune Campus, Ganeshkhind, Pune 411 007, Maharashtra, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Leishmania donovani causative agent for visceral leishmaniasis is transmitted to humans by sandfly vector. It is caused by an obligate intra-macrophage protozoan parasite Leishmania. It accounts for high morbidity and mortality. There are two phases of development in Leishmania parasites (i) intra-macrophage 'amastigote form and (i) in sandfly as promastigote' form. Therapeutic drugs in clinic are pentavalent Antimonials, Amphotericin-B (Parentral drug) and Miltefosine. Vaccines are still not available for leishmaniasis. Focus on control measures are therefore directed on vector control or more appropriately chemotherapy. Proper targets are selected, such as an enzyme, through screening of the biochemical influence of compounds (potential drugs) on this target. However, their severe toxicity to normal cells and the high resistance of the causative agent, L donovani, has necessitated the need for discovery of new alternative therapy. In the present study, we have evaluated Aerva sanguinolenta for anti-leishmanial potential using L donovani promastigotes (Dd8, WHO Strain). A. sanguinolenta is an ornamental plant which is used to cure various diseases and skin lesions. The whole plant ethanolic extract from Aerva sanguinolenta was investigated for anti-leishmanial activity. A. sanguinolenta showed significant anti-leishmanial activity as observed by significant ICS0 levels and decrease in acid phosphatase, arginase, and protein levels as compared with medium alone and Amphotericin-B. It increased nitric oxide levels, which is indicative of oxidative stress in parasites. Present study shows that A. sanguinolenta is a good anti-leishmanial agent. Further studies are warranted to check parasite clearance in an intra-macrophage model.

Cite this article:
Kharat, Patole and Pai (2016). In Vitro Antileishmanial Activity of the Medicinal Plant Extract of Aerva sanguinolenta (Linn) Blume. Journal of Ravishankar University (Part-B: Science), 29(1), pp.98-99.


References not available.

Related Images:



Recent Images



Chlorpyrifos Mediated Amendment in Protein Profiling of Bacillus spp.
Structural, Compositional and Photoluminescence Studies of Li4SrCa(SiO4)2: Eu3+ Red Phosphor Synthesized by Solid State Reaction Method
Formulation and Characterization of Magnetically Responsive Mesalamine Microspheres for Colon Targeting
Development of Non-Invasive Technique for Heart Rate Detection Using Facial Videos
Human Part Semantic Segmentation Using CDGNET Architecture for Human Activity Recognition
Lifestyle Modification Therapy and its Effect on Weight Status of Non-Alcoholic Male Liver Disease Patients
Exploring Life Cycle Analysis in Developing Sustainable Communities in Chhattisgarh
Monitoring the Concentration of Lead in the Industrial Wastewater of Baloda Bazar District
Impact of Climate Change on Paddy Yield in Bastar District of Chhattisgarh
Chemical Pollutants: A Concern to The Environment

Tags


Recomonded Articles:

Author(s): Thiyagarajan Sivaprakasam; Sandeep Ravi Varma; Ilavarasu Arumugam; Sunil Prabhu; Rangesh P

DOI:         Access: Open Access Read More

Author(s): Mahesh Kumar Kharat; Milind Patole; Kalpana Pai

DOI:         Access: Open Access Read More

Author(s): Debayan Goswami; Rashmi Das; Durbadal Ojh; Amit Kar; Pulok K Mukherjee; Debprasad Chattopadhyay

DOI:         Access: Open Access Read More

Author(s): Mohammad A Rashid

DOI:         Access: Open Access Read More

Author(s): Manmohan S Jangdey; Anshita Gupta; Shailendra Saraf; Swarnlata Saraf

DOI:         Access: Open Access Read More

Author(s): R Logesh; Amrendra Kumar Tiwari; Pritorthi Bhattacharjee; Pulok K Mukherjee; S Rajan

DOI:         Access: Open Access Read More