Herbs have been extensively used since renaissance for benefit of mankind. Those used in medicine, are recognized to have bioactive compounds having medicinal properties like antioxidant, anti-inflammatory, antimicrobial, hypolipidemic, antimutagenic, anticarcinogenic, etc. The radical scavenging or antioxidant benefits of botanical bioactive compounds provide opportunities to utilize their potential for prevention of drug related haemolytic toxicities, preferably because the toxicity is caused due to oxidative stress. Antioxidants derived from plants, such as flavonoids and related phenolic compounds are beneficial compounds that protect cells against oxidative destruction. Red blood cell membrane contains high amount of polyunsaturated fatty acids that are vulnerable to oxidative damage, which leads to cell lysis and predispose to haemolytic anaemia Therefore, antioxidants that scavenge reactive oxygen species or chelate metal transition ions have pronounced value in preventing the drug induced haemolytic anaemia. Species like Eriobotrya japonica, Clinacanthusnutans, Silybummarianum, Maytenusroyleanus, Psidium guajava are some of the explicit examples Researchers are continuously discerning strategies to explore their antioxidant capabilities in order to reduce drug induced hemolysis. Among the various medicinal plants, some with potential antihemolytic effects have been validated but many such plants remain to be explored and can be investigated in the near future. The objective of this study is to furmish a comprehensive review on plants bearing antihemolytic activity and their scope in reducing drug induced hemolysis.
Cite this article:
Jeswani and Ajazuddin (2016). Bioactive Natural Compounds as Antihemolytic Agents: A Review. Journal of Ravishankar University (Part-B: Science), 29(1), pp.165-166.