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Author(s): Taranjeet Kukreja, Arushi Saloki, Swarnlata Saraf

Email(s): swarnlatasaraf22@gmail.com

Address: University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur – 492010, Chhattisgarh, India.
University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur – 492010, Chhattisgarh, India.
University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur – 492010, Chhattisgarh, India.
*Corresponding author: Prof. Swarnlata Saraf (swarnlatasaraf22@gmail.com)

Published In:   Volume - 37,      Issue - 1,     Year - 2024

DOI: 10.52228/JRUB.2024-37-1-3  

ABSTRACT:
By definition, an open injury is any severe break in the continuity of the skin and deep tissue. Because contusions are healed injuries, the term given above does not apply to them. The classification of injuries is essential for both therapeutic and medico-legal purposes. Burn injuries are comparable to other injuries in that they require the same basic principles for healing and care, but they differ in that they have a greater impact on the patient's overall health and are essential to the patient's eventual survival, the development of deformity, and rehabilitation. Treatment of burn injuries has always been the responsibility of burn specialists. Both local and systemic therapy have long been advised for treating burn injuries and minimizing burn scars. This review summarizes the treatment of burn injuries brought on by a variety of physical and chemical agents requires unique regimens that are completely different from those used to treat any other traumatic injuries. Other acute injuries that undergo entire blood loss result in shock, but major burns that experience significant plasma loss due to increased capillary permeability result in distress. Burn injuries are initially sterile compared to the majority of other injuries, however, due to the immunocompromised state of burn patients and injury infection frequently ends in death in serious burns. We have discussed the pathophysiology, primary care therapies, nanomaterials used in injury healing therapy and various nanoparticles in injury healing process for burn injuries in this review.

Cite this article:
Kukreja, Saloki and Saraf (2024). A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options. Journal of Ravishankar University (Part-B: Science), 37(1), pp. 32-48. DOI:DOI: https://doi.org/10.52228/JRUB.2024-37-1-3


References

[1]    B. Ghosh, M. Mukhopadhyay, and D. Bhattacharya, “Biopolymer-based nanofilms for the treatment of burn injuries,” Biopolym. Nano Film. Appl. Food Packag. Injury Heal., pp. 311–336, Jan. 2021, doi: 10.1016/B978-0-12-823381-8.00005-3.

[2]    “Burns: Types, Symptoms, and Treatments.”

[3]    J. L. Hunt, B. D. Arnoldo, and G. F. Purdue, “Chapter 4 - Prevention of burn injuries,” D. N. B. T.-T. B. C. (Fourth E. Herndon, Ed. London: W.B. Saunders, 2012, pp. 47-55.e2. doi: https://doi.org/10.1016/B978-1-4377-2786-9.00004-7.

[4]    “The global burden of disease : 2004 update.”

[5]    “Institute for Health Metrics and Evaluation |.”

[6]    “Burns | National Health Portal Of India.”

[7]    J. W. L. Davies, “The problems of burns in India,” Burns, vol. Suppl 1, no. SUPPL. 1, 1990.

[8]    L. K. Branski, D. N. Herndon, and R. E. Barrow, “Chapter 1 - A brief history of acute burn care management,” D. N. B. T.-T. B. C. (Fourth E. Herndon, Ed. London: W.B. Saunders, 2012, pp. 1-7.e2. doi: https://doi.org/10.1016/B978-1-4377-2786-9.00001-1.

[9]    M. D. Peck, “Epidemiology of burns throughout the world. Part I: Distribution and risk factors,” Burns, vol. 37, no. 7, pp. 1087–100, Nov. 2011, doi: 10.1016/j.burns.2011.06.005.

[10]  K. R. Kasten, A. T. Makley, and R. J. Kagan, “Update on the critical care management of severe burns,” J. Intensive Care Med., vol. 26, no. 4, pp. 223–236, 2011, doi: 10.1177/0885066610390869.

[11]  S. Taylor, J. Jeng, J. R. Saffle, S. Sen, D. G. Greenhalgh, and T. L. Palmieri, “Redefining the outcomes to resources ratio for burn patient triage in a mass casualty,” J. Burn Care Res., vol. 35, no. 1, pp. 41–45, 2014, doi: 10.1097/BCR.0000000000000034.

[12]  S. V. Mahadevan and G. M. Garmel, An introduction to clinical emergency medicine, 2nd ed. Cambridge: Cambridge University Press, 2012.

[13]  M. Jeschke, Handbook of Burns Volume 1: Acute Burn Care. Springer, 2012.

[14]  M. Peden, World report on child injury prevention. Geneva, Switzerland: World Health Organization, 2008.

[15]  S. Eisen and C. Murphy, Training in paediatrics : the essential curriculum. Oxford: Oxford University Press, 2009.

[16]  R. K. Jutla and D. Heimbach, “Love burns: An essay about bride burning in India,” J. Burn Care Rehabil., vol. 25, no. 2, pp. 165–70, Mar. 2004, doi: 10.1097/01.bcr.0000111929.70876.1f.

[17]  J. A. Haagsma et al., “The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013,” Inj. Prev., vol. 22, no. 1, pp. 3–18, Feb. 2016, doi: 10.1136/INJURYPREV-2015-041616.

[18]  K. S. Wood and P. V Gordon, “Neonatal and Pediatric Transport,” Tintinalli’s Emerg. Med. A Compr. Study Guid., pp. 16–21, 2011.

[19]  G. Arturson, “Pathophysiology of the burn injury.,” Ann. Chir. Gynaecol., vol. 69, no. 5, pp. 178–190, 1980.

[20]  “Weissman1990 Estado Del Arte 1.”

[21]  Z. Xing et al., “IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses,” J. Clin. Invest., vol. 101, no. 2, pp. 311–320, 1998, doi: 10.1172/JCI1368.

[22]  W. L. Biffl, E. E. Moore, F. A. Moore, and V. M. Peterson, “Interleukin-6 in the injured patient. Marker of injury or mediator of  inflammation?,” Ann. Surg., vol. 224, no. 5, pp. 647–664, Nov. 1996, doi: 10.1097/00000658-199611000-00009.

[23]  A. Gosain and R. L. Gamelli, “A primer in cytokines.,” J. Burn Care Rehabil., vol. 26, no. 1, pp. 7–12, 2005, doi: 10.1097/01.bcr.0000150214.72984.44.

[24]  G. D. Kay, “Prolonged Survival of a Skin Homograft in a Patient With Very Extensive Burns,” Ann. N. Y. Acad. Sci., vol. 64, no. 5, pp. 767–774, 1957, doi: 10.1111/j.1749-6632.1957.tb52471.x.

[25]  L. F. Rose and R. K. Chan, “The Burn Injury Microenvironment.,” Adv. injury care, vol. 5, no. 3, pp. 106–118, Mar. 2016, doi: 10.1089/injury.2014.0536.

[26]  V. Suvatte, C. Chuntrasakul, M. Tuchinda, N. Srimaruta, and A. Assateerawatts, “8ImmunologicalIncompetenc-inBurnPatientsAPJAIVol1No2DecP112.pdf.”

[27]  J. B. Grogan, “Altered neutrophil phagocytic function in burn patients,” J. Trauma, vol. 16, no. 9, pp. 734–738, 1976, doi: 10.1097/00005373-197609000-00009.

[28]  A. Göebel et al., “Injury induces deficient interleukin-12 production, but interleukin-12 therapy  after injury restores resistance to infection.,” Ann. Surg., vol. 231, no. 2, pp. 253–261, Feb. 2000, doi: 10.1097/00000658-200002000-00015.

[29]  R. N. Stephan, A. Ayala, J. M. Harkema, R. E. Dean, J. R. Border, and I. H. Chaudry, “Mechanism of immunosuppression following hemorrhage: defective antigen  presentation by macrophages.,” J. Surg. Res., vol. 46, no. 6, pp. 553–556, Jun. 1989, doi: 10.1016/0022-4804(89)90019-x.

[30]  O. Loughlin and L. S. Sorell, “United States Patent [ 191 Date of Patent :,” vol. 2, no. 12, 1988.

[31]  D. G. Burleson, A. D. J. Mason, and B. A. J. Pruitt, “Lymphoid subpopulation changes after thermal injury and thermal injury with  infection in an experimental model.,” Ann. Surg., vol. 207, no. 2, pp. 208–212, Feb. 1988, doi: 10.1097/00000658-198802000-00016.

[32]  B. Muthiah, F. K. Ofori-kuma, C. B. Rao, K. Mealy, and J. B. O’Mahony, “A review of a five-year experience with the open mesh repair for inguinal hernia,” Ir. J. Med. Sci., vol. 171, no. 1, p. 24, 2002, doi: 10.1007/BF03170369.

[33]  J. H. N. Wolfe, A. V. O. Wu, I. Saporoschetz, J. A. Mannick, and N. E. O. Connor, “and Impaired Lymphocyte Blastogenesis in Burn Patients,” 2015.

[34]  P. Casson, A. C. Solowey, J. M. Converse, and F. T. Rapaport, “Delayed hypersensitivity status of burned patients.,” Surg. Forum, vol. 17, pp. 268–270, 1966.

[35]  M. G. Dehne, A. Sablotzki, A. Hoffmann, J. Mühling, F. E. Dietrich, and G. Hempelmann, “Alterations of acute phase reaction and cytokine production in patients following  severe burn injury.,” Burns, vol. 28, no. 6, pp. 535–542, Sep. 2002, doi: 10.1016/s0305-4179(02)00050-5.

[36]  D. Church, S. Elsayed, O. Reid, B. Winston, and R. Lindsay, “Burn injury infections.,” Clin. Microbiol. Rev., vol. 19, no. 2, pp. 403–434, Apr. 2006, doi: 10.1128/CMR.19.2.403-434.2006.

[37]  “Burn Complications | Burn Injury Guide.”

[38]  “Microbial Infection of Burn Injuries - microbewiki.”

[39]  N. S. Gibran and D. M. Heimbach, “Current status of burn injury pathophysiology.,” Clin. Plast. Surg., vol. 27, no. 1, pp. 11–22, Jan. 2000.

[40]  L. T. Vo, G. D. Papworth, P. M. Delaney, D. H. Barkla, and R. G. King, “A study of vascular response to thermal injury on hairless mice by fibre optic confocal imaging, laser doppler flowmetry and conventional histology,” Burns, vol. 24, no. 4, pp. 319–324, 1998, doi: 10.1016/S0305-4179(98)00028-X.

[41]  D. L. Steed, “The role of growth factors in injury healing.,” Surg. Clin. North Am., vol. 77, no. 3, pp. 575–586, Jun. 1997, doi: 10.1016/s0039-6109(05)70569-7.

[42]  “madden1971.pdf.”

[43]  R. Gomez et al., “Causes of mortality by autopsy findings of combat casualties and civilian  patients admitted to a burn unit.,” J. Am. Coll. Surg., vol. 208, no. 3, pp. 348–354, Mar. 2009, doi: 10.1016/j.jamcollsurg.2008.11.012.

[44]  E. F. Keen et al., “Incidence and bacteriology of burn infections at a military burn center,” Burns, vol. 36, no. 4, pp. 461–468, 2010, doi: 10.1016/j.burns.2009.10.012.

[45]  M. A. Albrecht et al., “Impact of Acinetobacter Infection on the Mortality of Burn Patients,” J. Am. Coll. Surg., vol. 203, no. 4, pp. 546–550, 2006, doi: 10.1016/j.jamcollsurg.2006.06.013.

[46]  E. E. Horvath et al., “Fungal injury infection (not colonization) is independently associated with  mortality in burn patients.,” Ann. Surg., vol. 245, no. 6, pp. 978–985, Jun. 2007, doi: 10.1097/01.sla.0000256914.16754.80.

[47]  S. Sarabahi, V. K. Tiwari, S. Arora, M. R. Capoor, and A. Pandey, “Changing pattern of fungal infection in burn patients,” Burns, vol. 38, no. 4, pp. 520–528, 2012, doi: 10.1016/j.burns.2011.09.013.

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