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Author(s): Manmohan L Satnami, Kuleshwar Patel, Sandeep K Vaishnav, Kumudini Chandraker, Jyoti Korram, Rekha Nagwanshi, Kallol K Ghosh

Email(s): manmohanchem@gmail.com

Address: School of Studies in Chemistry, P. Ravishankar Shukla University, Raipur 492 010, India
Department of Chemistry, Govt. Madhav Science PG College, Ujain -456 010, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
The determination of thiol based biological molecules and drugs, such as cysteine (Cys). glutathione (GSH). a- lipoic acid, and sodium 2-sulfanylethane sulphonate in human plasma are becoming progressively more important, due to exploration of their essential role in numerous biological pathways. Herein we demonstrate the development of a highly sensitive colorimetric method for the determination of medicinally important thiol drugs (I-IV), based on aggregation of the citrate capped silver nanoparticles (Ag NPs). This was exploited from high affinity of thiols towards the Ag NPs surface, which could tempt replacement of the citrate shell by the thiolate shell of target molecules, resulting in aggregation of the NPs through intermolecular electrostatic interaction or hydrogen-bonding. Because of aggregation, the plasmon band at around 396 nm decreases gradually, along with formation of a new red shifted band. The calibration curves are derived from the intensity ratios of absorbance at SAu wR sen vompound I-IV respectively, to the original wavelength of 396 nm. The calibration curves display a linear relation in the range of 1uM-100 uM (tor I), SuM-200 uM (for ) 0 M LO0M (for III) and 10 uM -150 pM (for IV), respectively. The obtained detection limits (3a) were found to be 1.5 pM, 6.6 pM, 10.5 pM and 11.6 µM for compound I-IV, respectively. The proposed method has been successfully applied for the detection of thiol compounds in different kind of real samples.

Cite this article:
Satnami, Patel, Vaishnav, Chandraker, Korram, Nagwanshi and Ghosh (2016). Silver Nanoparticles Based Spectroscopic Technique for the Determination of Medicinally Important Thiol Compounds. Journal of Ravishankar University (Part-B: Science), 29(1), pp.159-160.


References not available.

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