A new simple spectrophotometric method was developed for the determination of binary mixtures of Ambroxol hydrochloride (AMB) and Guaifenesin (GUF), without prior separation. The method is based on the multi-wavelength technique i.e. classical least square (CLS) method. The liquid formulation of Ambroxol hydrochloride and Guaifenesin was determined by classical least square at 244 of AMB and at 225 and 272 nm of GUF. Beer's law was obeyed in 5-50 µg/ml of each drug and calibration equation was obtained. The obtained result was shown that the mean recoveries were more than 98% for AMB and GUF, respectively. The proposed spectrophotometric method was validated and successfully applied for the assay of drug combination in several laboratory-prepared mixtures and commercial pharmaceutical formulations.
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Cite this article:
Singh and Daharwal (2016). Development of Classical Least Square Method for the Determination of Ambroxol hydrochloride and Guaifenesin in Cough Syrup. Journal of Ravishankar University (Part-B: Science), 29(2), pp.29-34.