The kinetic solvent isotope effects on the acid catalysed hydrolysis of three unsubstituted hydroxamic acids of the type R-C6H4.CO NHOH (R=H, 4-CH3O and 3-Cl) have been studied in D2SO4 and DCl in 10% (v/v) dimethyl sulphoxide at 550c. The results particularly the change in the magnitude of kinetic solvent isotope effect on increasing acidityare consistent with a reaction involving a• fast pre-equilibrium followde by bimolecular deuterium oxide or water attack as a nucleophile on protonated species of hydroxamic acid.
Cite this article:
Ghosh and Krishnanl (1993). Kinetic solvent Deuterium effect on Hydrolysis of unsubstituted Hydroxamic Acids. Journal of Ravishankar University (Part-B: Science), 6(1), pp. 37-41.