Sisymbrium irio Linn (Family: Cruciferae) [Seeds] is folklore medicine commonly known as Khakshi, is known to have wide range of Pharmacological activity. The seed is used as expectorant, stimulant, and asthma externally used as stimulating poultice. We reported previously the protective action of Sisymbrium irio in experimental bronchial asthma. The present study was designed to assess the protective effect of Sisymbrium irio secds on in vitro mast cell stabilization and active anaphylaxis model in experimental animals. The present investigation of ethanolic extract of the seeds of Sisymbrium irio was found to have protective actions against histamine aerosol induced on broncho- constriction, mast cell degranulation induced by Comp. 48/80 and active anaphylaxis. The present finding of Sisymbrium irio because seed is rich in glycosides, steroids, alkaloids and flavonoids components present in extracts. The steroids, flavonoids and alkaloids have been reported to be effective in clinical asthma
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