Abstract View

Author(s): L Sathiyanarayanan

Email(s): pharmsathiya@gmail.com

Address: Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Herbal medicine, the backbone of traditional medicine, has been playing an important role on the human health f welfare for a long period. Patients suffered from various ailments consume herbal remedies along with prescription dicines with or without the knowledge of health care practitioner. The effectiveness of using herbal medicine in mbination with modern pharmaceuticals, and the possible adverse effects from herb-drug interactions remain to be erified. The challenge in herb drug interaction studies is that the animal pharmacokinetic studies cannot be extrapolated to umans due to the differences in the CYP450 enzymes. However the pharmacokinetic and dynamic studies can alarm the earchers to involve in further research. RA is a condition that causes inflammation of the lining of the joint or synovial membrane, which affects people in all age groups and is more common in women. The treatment strategy for RA includes Bon-steroidal anti-inflammatory drugs, glucocorticoids, Disease modifying anti-rheumatic drugs (DMARDS), and biological response modifiers. Andrographis paniculata Nees (AP) is widely used for the RA treatment in south India. The anti- inflammatory activity of the AP extract is attributed to Andrographolide. AG and AP extract (APE) significantly induced the expression of the cytochrome P450 (CYP) family, CYPIAI and CYPIA2. APE inhibited the activities of CYPIA2, CYP2C in rat and human liver microsomes. Prompted by these findings the herb drug interaction of AP and AG was investigated with selected anti rheumatic drugs. This presentation elaborates the Herb drug interaction by taking few studies carried out using AP and AG.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Modeling of Abnormal Hysteresis in CsPbBr3 based Perovskite Solar Cells
Impact of Melatonin on Growth and Antioxidant Activity of Cicer arietinum L. Grown under Arsenic Stress
Assessment of Cymoxanil in Soil, Water and Vegetable Samples
Various Techniques of MPPT Based Charge Controller & Comparison of A/C with D/C Home Appliances - A Review
Need of Gallium Recovery from Waste Samples: A Review
Higher Order Statistics Based Blind Steg analysis using Deep Learning
Covid-19 related School Closure Impact on School going Children & Adolescents of Raipur, Chhattisgarh
Determination of Pentachlorophenol in Environmental Samples by Spectrophotometry
Simple and Cost Effective Polymer Modified Gold Nanoparticles Based on Colorimetric Determination of L-Cysteine in Food Samples
Investigation on Design and Device Modeling of High Performance CH3NH3PbI3-xClx Perovskite Solar Cells

Tags


Recomonded Articles: