Abstract View

Author(s): Anand Kar, Sunanda Panda

Email(s): karlife@rediffimail.com , spanda4@ rediffmail.com

Address: School of Life Sciences, Devi Ahilya University, Indore-452017, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Cardiovascular diseases (CVDs) leading to heart failure and heart attack are increasing alarmingly. Obviously discovery of the suitable medicines are the need of the hour. While some research work has already been done on the mgulation of CVDS using plant extracts, on active compounds nothing much is known. Our recent findings on plant extracts and their active compounds are being presented here. Several investigations were made on the crude extracts of some plants to unravel their efficacy to regulate chemically induced cardiovascular problems in the laboratory animals. Once the effectiveness of the crude extracts were ascertained, attempts were made to isolate different phytochemicals and to evaluate their possible cardio-protective efficacy. Tissue lipid peroxidation (LPO) and antioxidant status and some cardiac marker enzymes were considered as major indices. Two active compounds from T.f. gratium seeds and one each from M. oleifera leaf and C roseus leaf were found to be quite effective in the amelioration of isoproterenol (aSO-induced myocardial dysfunctions in rats. Most likely the efficacy of the compounds were due to their structural specificity and free radical scavenging action. The test compounds appeared to be safe at certain concentration as they did not enhance tissue LPO and enhanced the antioxidant status. Further research using these test phytochemicals will certainly help in the discovery of new drugs for the prevention and treatment of cardio vascular diseases.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Herbal Alternatives for Oral Health:  Mechanistic Exploration with their Market Potential
Time of the Day Variability in Pit-Building Behavior of Antlion Larvae
A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
Enhanced antioxidant activity in Curcuma caesia Roxb. microrhizomes treated with silver nanoparticles
Studies on the Interaction of Imidazolium Ionic Liquids with Human Serum Albumin
Basic and Advanced Logical Concept Derived from Surface Enhanced Infrared Spectroscopy (SEIRS) as Sensing Probe for Analysis of Chemical Species: A Brief Review
Soil Erosion Risk Estimation by using Semi Empirical RUSLE model: A case study of Maniyari Basin, Chhattisgarh
An Estimator of Population Variance Using Multi-Auxiliary Information
Microemulsion as Novel Drug Delivery for Fungal Eye Infection
Potential of Bioactive Compounds for Atopic Dermatitis

Tags


Recomonded Articles: