Abstract View

Author(s): DM Kokare, DN Aru, AP Bharne, NK Subhedar

Email(s): kokaredada@yahoo.com

Address: Department of Pharmaceutical Sciences, RTM Nagpur University, Nagpur 440 033, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI: Not Available

ABSTRACT:
Plumbagin is a low molecular weight lipophilic phytochemical, emerged as a novel antioxidant and neuroprotective agent. Although, neuroprotective effects of plumbagin have been studied in the Parkinson's disease, its efficacy is largely unknown in the other neurodegenerative disorders including Alzheimer's disease (AD). Herein we established the effect of plumbagin (0.1, 0.3 and 0.5 mg/kg. intraperitoneal (ip)] on learning and memory in AD-like condition in mice by using Morris water maze (MWM). AD-like mouse model was developed by intracerebroventricular (icv) administration of single dose of streptozotocin (3 mg/kg). In addition, nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway inhibitor, trigonelline (3, 10, 30 mg/kg, ip) has been administered to study the underlying mechanism in normal mice. Present results revealed a bell shaped efficacy of plumbagin in mice. While plumbagin at 0.3 mg/kg dose significantly lowered the escape latency, 0.1 or 0.5 mg/kg, both, did not affect the escape latency significantly as compare to saline treated mice, thus considered as ineffective. Further, administration of trigonelline dose-dependently (at 10 and 30 mg/kg, ip) increased the escape latency, suggesting memory impairment. Moreover pre- treatment of trigonelline blocked the nootropic effect of plumbagin in MWM. We conclude that plumbagin produce memory enhancing effect on AD-like condition in mice, perhaps via Nrf2/ARE pathway.

Cite this article:
Kokare, Aru, Bharne and Subhedar (2016). Plumbagin Enhances Spatial Learning and Memory in the Mouse Model of Alzheimer's Disease. Journal of Ravishankar University (Part-B: Science), 29(1), pp.142-143.


References not available.

Related Images:



Recent Images



Performance Evaluation of Spectrogram Based Epilepsy Detection Techniques Using Gray Scale Features
Perovskite Solar Cells an Efficient, Low Cost, Emerging Photovoltaic Technology
Spectrophotometric Determination of Phenthoate in Vegetables and Fruit Samples of Kabirdham (Chhattisgarh)
Flotation-Dissolution-Spectrophotometric Determination of Phorate in Various Environmental Samples
Preparation, Fabrication and Characterization of Sol-Gel ZnO Thin Films for Organic Solar Cells
Distribution of Some Selected Surface Active Agents (SAAs) in the Aquatic and Global Environment with Their Toxic Impact: A Comprehensive Review
Intriguing Clinical and Pharmaceutical Applications of IERs: A Mini Review
Soil Contamination in the Industrial Vicinity of Bemetara and Raipur District of Chhattisgarh, India
An Extractive Spectrophotometric Method for the Determination of Pymetrozine in Various Ecological Samples of Bilaspur District (C.G.)
Development and Characterization of Quercetin Loaded Nanoparticle for Skin Cancer

Tags


Recomonded Articles: