Abstract View

Author(s): Afifah B Sutjiatmo, Elin Yulinah Sukandar, Siti Ernawati, Suci Nar Vikasari

Email(s): fifahbs@yahoo.com

Address: Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Biosciences and Biotechnology Research Center, InstitutTeknologi Bandung, Bandung Indonesia
Schools of Pharmacy, InstitutTeknologi Bandung. Bandung. Indonesia.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Mangosteen (Garcinia mangostana Linn) pericarp traditionally is used to treat several diseases, such as hyperuricemia, hypercholesterolemia, constipation, and as antiinflamation agent. This study was done to evaluate the inhibiton effect of aqueous extract of mangosteen pericarp in hypercholesterolemia animal models. Aqueous extract of mangosteen periscarp were made using boiled water and the extract were dried at 60°C. The extract was adminestered orally at doses of 720 and 1440 mg/kg bw, and simvastatin at dose 15.3 mg/kg bw was used as comparator. Male Wistar rats with high cholesterol feed and prophylthiouracl (PTU) as hypercholesterolemia inducing agent is used as animals model of hypercholesterolemia. Total blood cholesterol level was observed once a week over 4 weeks. The result showed that the increasing of total cholesterol level was inhibited after 14 days administration of aqueous xtract of mangosteen pericarp at doses of 720 abd 1440 mg/kg bw compared to control group (p0.05) and similar to simvastatin 15.3 mg/kg bw (p>0.05). The mangostecn extract at dose of 720 mg/kg bw could inhibit total cholesterol level by cumulative 217.9% over 4 weeks, dose 1440 mgfkg bw could inhibit by cumulative195.7%, and simvastatin 15.3 mg/kg bw could inhibit by cumulative 336.67%.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



Potential of Bioactive Compounds for Atopic Dermatitis
Time-Frequency Image-based Speech Emotion Recognition using Artificial Neural Network
Zn Fortification Influential Impact on the Productivity of Calocybe indica Mycelium
Enhanced ACO in clustering algorithm for QoS in WSN enabled IoT
A Modified Regression Type Estimator Using Two Auxiliary Variables
Sziklai Pair based Small Signal Amplifier with BJT-MOSFET Hybrid Unit at 180nm Technology
Rice Straw-Derived Carbon Integrated with PANI: As an Electrode Material for High-performance Supercapacitor
Extraction, Characterisation, Biological Properties and Applications of Essential Oils: A Review
Biopolymeric Materials in the Management of Diabetic Wound Healing: A Comprehensive Review
Entomopathogenic Fungi: Nature

Tags


Recomonded Articles: