ABSTRACT:
Advancement in the knowledge of molecular mechanisms, cellular biology and genomics not only increased the number of molecular targets but also demanded shorter drug discovery timelines. The chemistry of natural products has been investigated thoroughly in the recent decades, resulting in the better understandıng. Computational methods have recently shown to be an important complementary tool for study of pharmacological activity of natural compounds. Bioprocess engineering has played a successful role in developing and producing pharmaceuticals from fungal and bacterial origin. The principles of this technology have already been exploited for commercial production of vaccines and therapeutic proteins from animal origin. The potential and knowledge of Bioprocess engineering has not yet fully exploited for commercial production of biopharmaceuticals from herbal origin. Scale up of suspension cultures, tissue and organ cultures of medicinal plants can overcome most of the shortcomings of herbal medicines obtained from natural resources. Withanolides, for example can interact with variety of IAPS with distinct architecture such as BIR region. At the same time these withanolides can interact with diverse group of proteins vhich are involved in inhibition of apoptosis. The bioprocess for production of herbal biopharmaceuticals from Withania somnifera with defined chemo-profile has been developed.