ABSTRACT:
Migraine is a neurological disease characterized by the severe headache, which is associated with the nausea, vomiting and extreme sensitivity to light and sound. These conditions account for disturbance of patient's routine lifestyle. The drug of choice to overcome the severe headache of migraine is Sumatriptan succinate and Propranolol HCI as a prophylaxis to reduce the frequency of attacks. The objective of this research work was to overcome the above problem and to establish a combination of immediate release pellets of Sumatriptan Succinate and sustained release pellets of Propranolol HClfor the effective treatment of migraine. The formulations of immediate release pellets (batches F1- F9) were prepared by using super disintegrants like Croscarmellose sodium, Sodium starch glycolate, Crospovidone and the sustained release pellets (batches F10-FI5) were prepared using release retarding agents like HPMC K100M, Ethyl cellulose. Both sustained and immediate release pellets were evaluated for flow properties and in-vitro drug release for 12 hours. All the formulations obey Korsmeyerpeppas order release kinetics and the mechanism of drug release was found to be nonfickian diffusion. The results suggest that the developed combination of immediate release Sumatriptan Succinate with sustained release Propranolol HCI could perform therapeutically better and with improved efficacy than conventional dosage forms. The same technique can be applied by using natural excipients from herbal origin.