Abstract View

Author(s): Shikha Srivastava, Manju R Singh, Deependra Singh

Email(s): Shikha_ceutics@yahoo.co.in

Address: University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur - 492 010, India.

Published In:   Volume - 29,      Issue - 1,     Year - 2016

DOI:

ABSTRACT:
Guggulsterone had been shown to be ef guggulsterone is a concern for such treatment. This work aims at the development of oral drug delivery system by controlled release of guggulsterone, loaded in beads for the management of rheumatoid arthritis. The beads of guggulsterone prepared using the solvent evaporation method. The physio-chemical characterisation of beads was carried out to obtain information about particle size distribution, drug loading efficiency, morphology, thermal properties, polymorphism and release trends in phosphate-buffered saline at pH 7.4 and 378°C. The beads were found to be biocompatible as evidenced fromin vitro and in vivo studies using a rabbit synovial cells and Wistar rats, respectively. Guggulsterone release from beads of selected formulations showed biphasic nature due to initial burst effect followed by a controlled release. These results suggest that optimised - guggulsterone loaded beads may be the viable strategy for controlled release of guggulsterone in the joint for more than 30 days by oral administration to treat rheumatoid arthritis. ive in the management of arthritis. However, bioavailability of.

Cite this article:
Not Available


References not available.

Related Images:



Recent Images



A Review on role of Congestion Control Techniques in Internet of Things
Recent Advancement in Capsule: Emerging Novel Technologies and Alternative Shell Materials for Wide Range of Therapeutic Needs
Effect of L-Dopa on cypermethrin induced reproductive conditions in female Japanese quail, Coturnix coturnix japonica
Preparation, Characterization, and Applications of Albumin Serum-Based Nanoparticles
Study of developmental stages and morphometrics of Parthenium beetle in Bastar plateau agro-climatic zone of Chhattisgarh
PANI Incorporated Fe-MOF: As an Electrode Material for Supercapacitor
Surface Modified Magnetic Nanoparticles as an Efficient Material for Wastewater Remediation: A Review
A Review on Groundwater Pollution in India and their Health Problems
Incidence of Chronic fever in Raigarh Development Block of Raigarh District, Chhattisgarh, India
Study the optimization of Dijkstra’s Algorithm

Tags


Recomonded Articles: