ABSTRACT:
Acrylamide (ACR) is generated in many common foods during cooking at high temperature including French fries, potato and tortilla chips, bread crust, baked goods, breakfast cereals and coffee, etc. and causes hepato-renal toxicity. Resveratrol was evaluated against ACR induced hepatic and renal dysfunction. Five groups of 6 female albino rats in each were maintained for experiments. Group I served as control; groups 2-5 were exposed to ACR (40 mg/kg, oral) daily for 05 days. Group 2 served as experimental control and groups 3-5 were treated with resveratrol after 24 hrs of ACR toxicity at the doses of 10, 20 and 30 mg/kg respectively for 05 consecutive days. After 24 hrs of the last treatment, animals were cuthanized to determine various biochemical indices. Toxic response to ACR was noted in serum variables with deviated level of total protein, glucose, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, y-glutamyl transpeptidase, amylase, bilirubin, creatinine, creatinine kinase, urea, uric acid, tri-glycerides, cholesterol, high density lipoproteins and low density lipoproteins. ACR toxicity also deviated electrolyte concentrations in serum ie, Na, K, Ca", CI and pH. Blood profile was also found to be deviated from their control range. Treatment of resveratrol could reverse all the aforesaid variables towards control in a dose dependent manner and showed promising therapeutic potential against ACR induced hepatic and renal dysfunction.