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Author(s): Monika Jain, S.K. Chatterjee, Deepak Sinha

Email(s): drsinha333@gmail.com

Address: Government Polytechnic Bhatapara (C.G.)-493118, India
Government Girls College, Dhamtari (C.G.)-493773, India
Government Nagarjuna Post Graduate College of Science, Raipur (C.G.)-492002, India.

Published In:   Volume - 30,      Issue - 1,     Year - 2017


Cite this article:
Jain, Chatterjee and Sinha (2017). Conducto metric Studies on the Thermal Effects on Micellar Solubilization of Acetazolamide - A Diuretic Drug. Journal of Ravishankar University (Part-B: Science), 33(1), pp.74-77.



Journal of Ravishankar University-B, 30 (I &II), 74-77 (2017)

Conducto metric Studies on the Thermal Effects on Micellar Solubilization of Acetazolamide - A Diuretic Drug

Monika Jain, S.K. Chatterjee and Deepak Sinha

Government Polytechnic Bhatapara (C.G.)-493118, India

Government Girls College, Dhamtari (C.G.)-493773, India

Government Nagarjuna Post Graduate College of Science, Raipur (C.G.)-492002, India

Corresponding Author: drsinha333@gmail. com

[Received 03 November 2015; revised version 24 February 2018; accepted 27 February 2018]

Abstract: Drugs solubility is an important parameter for efficient absorption and drug delivery. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancement of drug solubility. Acetazolamide is a drug with diuretic properties. Conductivity measurement have been carried out to study the micellar behavior of anionic surfactant i.e., sodium dedocyl sulphate (SDS) and cationic surfactant i.e. cetyl trimethyl ammonium bromide (CTAB) in the absence and presence of a diuretic drug i.e. Diamox in the temperature range of 25°C – 45°C. From the measurements, various physicochemical and surface properties Critical micellar concentration (cmc), thermodynamic parameters (ΔG°m, ΔH°m , ΔS°m) have been determined. The negative value of ΔG°m shows spontaneity of solubilization process. All these parameters have been discussed in terms of drug-drug, drug-solvent and drug-surfactant interactions. This result shows that the solubility of Acetazolamide drug increases with increasing the concentration of both anionic and cationic surfactant. This study reveals that use of surfactant in pharmacy is an important tool for finding numerous applications.

Keywords: Micelles, Acetazolamide, solubilization, CMC.

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