Cite this article:
Jain, Chatterjee and Sinha (2017). Conducto metric Studies on the Thermal Effects on Micellar Solubilization of Acetazolamide - A Diuretic Drug. Journal of Ravishankar University (Part-B: Science), 33(1), pp.74-77.
Journal of Ravishankar
University-B, 30 (I &II), 74-77 (2017)
Conducto
metric Studies on the Thermal Effects on Micellar Solubilization of Acetazolamide
- A Diuretic Drug
Monika Jain, S.K. Chatterjee
and Deepak Sinha
Government Polytechnic
Bhatapara (C.G.)-493118, India
Government Girls College,
Dhamtari (C.G.)-493773, India
Government Nagarjuna Post
Graduate College of Science, Raipur (C.G.)-492002, India
Corresponding Author: drsinha333@gmail. com
[Received 03 November 2015; revised version 24
February 2018; accepted 27 February 2018]
Abstract: Drugs solubility is an
important parameter for efficient absorption and drug delivery. Thus, most
exigent phase of drug development practice particularly for oral dosage forms
is the enhancement of drug solubility. Acetazolamide is a drug with diuretic
properties. Conductivity measurement have been carried out to study the
micellar behavior of anionic surfactant i.e., sodium dedocyl sulphate (SDS) and
cationic surfactant i.e. cetyl trimethyl ammonium bromide (CTAB) in the absence
and presence of a diuretic drug i.e. Diamox in the temperature range of 25°C –
45°C. From the measurements, various physicochemical and surface properties
Critical micellar concentration (cmc), thermodynamic parameters (ΔG°m, ΔH°m ,
ΔS°m) have been determined. The negative value of ΔG°m shows spontaneity of
solubilization process. All these parameters have been discussed in terms of
drug-drug, drug-solvent and drug-surfactant interactions. This result shows
that the solubility of Acetazolamide drug increases with increasing the
concentration of both anionic and cationic surfactant. This study reveals that
use of surfactant in pharmacy is an important tool for finding numerous
applications.
Keywords: Micelles, Acetazolamide,
solubilization, CMC.
NOTE:
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