Author(s):
Dinesh Kumar Sharma, Bhabani S Nayak
Email(s):
dineshs405@gmail.com
Address:
Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore, Koraput, Odisha, India
National Center for Natural Resources, Pt. RSU, Raipur.
Published In:
Volume - 29,
Issue - 1,
Year - 2016
Cite this article:
Sharma and Nayak (2016). Preparation, Stabilization and Taste Making of Dry Powder for Oral Suspension of Cephalosporin Antibiotics. Journal of Ravishankar University (Part-B: Science), 29(1), pp.86-87.
OP-D05
Preparation,
Stabilization and Taste Making of Dry Powder for Oral Suspension of
Cephalosporin Antibiotics
Dinesh
Kumar Sharma and Bhabani S Nayak
Department
of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore,
Koraput, Odisha, India
National
Center for Natural Resources, Pt. RSU, Raipur.
Corresponding
author email: dineshs405@gmail.com
[Received
11 January 2016; accepted 12 January 2016]
Abstract:
Cephalosporin is known for its antimicrobial action, concentration-independent
bactericidal activity. Cephalosporin has excellent tolerance in children, with
almost no dose-related toxicity. These drugs also can be used safely in case of
hepatic or renal failure of the infants. Cefpodoxime is the active metabolite
of Cefpodoxime Proxetil. It is 3" generation broad spectrum antibiotic. It
belongs to - Lactam cephalosporin class of antibiotic. Its administration is
through oral route in pediatric and geriatric patients. It is extremely bitter
in taste. Cefpodoxime Proxetil is widely used for the treatment or prevention
of infectious bacterial diseases. Aim and objectives of this work is to improve
the taste of this highly bitter drug Cefpodoxime Proxetil through dispensing in
suspension form for the pediatric and geriatric patients. The aim was also to
prepare the stable formulation of Cefpodoxime Proxetil suspension and then to
compare all the evaluation parameters with marketed formulation. Major
challenge in this work is masking of the extreme bitterness of the antibiotic
drug for better patient compliance. Approaches used in formulation were taste
masking by the use of sweeteners, taste masking by the use of wet granulation
and taste masking by the use of dry granulation methods. On the basis of
results of preformulation study, we found that there were no incompatibility
between drug and excipients so the presumed excipients can be used for formulation
development. All in-vitro parameters of the trials were evaluated, out of which
dry granulation method has given better result as compared to innovator.
Keywords:
Taste masking techniques, Bitter drug. Cefpodoxime Prosetil, Granulation method