OP-C13

Development of Surface Engineered Nanocargoes Delivering Herbal Anticancer Drugs for Cervical Cancer

Anshita Gupta and Swarnlata Saraf

University Institute of Pharmacy, P. Ravishankar Shukla University, Raipur, C.G, India

Corresponding auchor email: anshita1912@gmail.com

[Received 15 January 2016; accepted 29 January 2016]

Abstract. Cervical cancer has shown its silent presence in last few decades. It has been observed that the number of cervical cancer cases in women has shown a steady growth in India as well as in our state. Various herbal drugs of indigencous origin have been extensively investigated for their anticancer activity against various forms of cancer including cervical cancer also However, the major disadvantage remained their poor aqueous solubility and less extent to reach the cellular targets. In the present research, an attempt has been done to develop targeted moieties of selected anticancer herbal drugs and evaluated them in vitro. The in vitro cellular uptake and antiproliferative potentials of these targeted nanocargoes were evaluated using Hela cell lines. The study results showed a very significant activity of herbal drug loaded targeted nanocargoes as compared to conventional drug.

Keywords: Cervical cancer, Nanocargoes, Herbal drugs, Anti proliferative, Cell targeting