Cite this article:
Kurrey (2016). Preparation of Amorphous Solid Dispersion of BCS Class II Drugs & Development of its Suitable Dosage Form for its Enhanced Solubility and Stability. Journal of Ravishankar University (Part-B: Science), 29(1), pp.80-81.
OP-C10
Preparation of
Amorphous Solid Dispersion of BCS Class II Drugs & Development of its
Suitable Dosage Form for its Enhanced Solubility and Stability
Neel Prakash Kurrey
University Institute of Pharmacy,
Pr. Ravishankar Shukla University, Raipur
Coresponding athor email: neelprakash22109@gmail.com
[Received
19 January 2016; accepted 29 January 2016]
Abstract:
Bioavailability is the measurement of the rate and extent that a
therapeutically active drug reaches the systemic circulation and becomes
available at the site of action. Possible methods for overcoming the poor bioavailability
of drug are enhancement of solubility and dissolution rate. Poor water
solubility of current active pharmaceutical ingredients (APIS) and new chemical
entities (NCES) is a major problem in the development of pharmaceutical dosage
forms. More than 40% of NCEs fall into Biopharmaceutical Classification System
(BCS) class II category having dissolution rate limited bioavailability,
whereas only 8% of new drug candidates have shown both high solubility and
permeability. Various approaches to overcome the poor aqueous solubility of
drug candidates have been investigated in drug research and development such as
salt formation, prodrug formation, particle size reduction, complexation,
micelles, microemulsions, nanoemulsions, nanosuspensions, solid-lipid
nanoparticle and solid dispersion. Amorphous solid dispersions are one of the
most promising strategies to improve the oral bioavailability of poorly
water-soluble drugs with water-soluble carriers have been reduced theincidence
of these problems and improved dissolution. A variety of excipients such as
polymers and surfactants may be used to prepare and stabilize the amorphous
form of a drug. Methods of preparing amorphous solid dispersions have been
successfully used in commercial production are melt extrusion, spray drying,
and rotary evaporation.
Keywords: Amorphous
solids; Bioavailability: Polymorph, Solid dispersion; Release