Author(s):
Manish M. Wanjari, Indu Sikarwar, Yadu Nandan Dey, Ajay Sharma, Sudesh Gaidhani, Ankush Jadhav
Email(s):
umamahiauhoa.com
Address:
National Research Institute for Ayurveda-Siddha Human Reuurce Development, Aamkho, Gwalior-474 009, Madhya Pradesh, India
Shri Ram College of Pharmacy, Hanmore - 476 444, Madhya Pradesh, India Central Council for Research in Ayurvedic Sciences, Ministry of AYUSIH New Delhi - 110 058, India.
Published In:
Volume - 29,
Issue - 1,
Year - 2016
Cite this article:
Wanjari, Sikarwar, Dey, Sharma, Gaidhani, Jadhav (2016). Chenopodium album Linn Leaves Prevent Ethylene Glycol-induced Urolithiasis in Rats. Journal of Ravishankar University (Part-B: Science), 29(1), pp.110.
OP-F23
Chenopodium
album Linn Leaves Prevent Ethylene Glycol-induced Urolithiasis in Rats
Manish M. Wanjari, Indu Sikarwar,
Yadu Nandan Dey, Ajay Sharma, Sudesh Gaidhani, Ankush Jadhav
National Research Institute for
Ayurveda-Siddha Human Reuurce Development, Aamkho, Gwalior-474 009, Madhya
Pradesh, India
Shri Ram College of Pharmacy,
Hanmore - 476 444, Madhya Pradesh, India Central Council for Research in
Ayurvedic Sciences, Ministry of AYUSIH New Delhi - 110 058, India
Corresponding author email:
umamahiauhoa.com
Received
15 January 2016, ccepted 17 February 2016]
Abstract: The leaves
of Chenopodium album Linn. are used in ethnomedicinal practices for correction
of kidney diseases and urinary stones. The present work aimed to investigate
effect of leaves of Chenopodium album on experimentally induced urolithiasis in
rats. Urolithiasis was induced in rats by administration 0.75% vv of ethy lene
glycol (EG) in distilled water. In addition, vehicle or methanolic (CAME) or
aqueous (CAAE) extract of the leaves of Chenopodium album each in the dose 100,
200 and 400 mg kg or standard drug- Cystone (750 mg kg) were administered daily
orally for 28 days. Urolithiasis was assessed by estimating biochemical
parameters in urine, plasma and kidney tissue. Calcium oxalate deposits were
also observed histologically. CAME or CAAE treatment (200 and 400 mg kg)
significantly attenuated the EG induced elevations in the urine and plasma
levels of calcium, phosphorus, urea, uric acid and creatinine along with
decrease in urinary oxalate. The treatments also decreased renal tissue oxalate
and deposition of oxalate crystals in kidney due to EG treatment. The effects
of CAME and CAAE were comparable to cystone while the lower dose of extract
(100mg/kg) was ineffective. The findings indicate the preventive effect of CAME
and CAAE which may be due to inhibitory effect on crystallization and stone
dissolution. The effect was attributed to the presence of phytochemicals like
flavonoids and saponins in the extract. In conclusion, Chenopodium album leaves
exhibited antilithiatic effect and validates its ethnomedicinal use in urinary
stones and kidney disorders.
Keywords: Bathua;
Kidney stones; Ethylene glycol; Cystone; Calcium oxalate