Cite this article:
Beck and Namdeo (2016). Investigation on Preliminary Phytoconstituents Screening and Antiinflammatory Activity of Carissa spinarum. Journal of Ravishankar University (Part-B: Science), 29(1), pp.194-195.
PP-F33
Investigation
on Preliminary Phytoconstituents Screening and Antiinflammatory Activity of
Carissa spinarum
Neeli Rose Beck and Kamta Prasad
Namdeo
SLT Institute of Pharmaceutical
Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur 495 006, India
Corresponding author email:
neeli05011974@ gmail.com
[Received
11 January 2016; accepted 13 January 2016]
Abstract: Carissa
spinarum is medicinal plants which are used in treatment of rheumatism,
purgative and snake repellent in India traditionally. 43 million people about
20 percent of population in United State are suffering from inflammatory
diseases. This number will be expected to 60 million by 2020. It is a disease
which is caused by physical trauma, harmful chemicals and some microbiological
agents. Some symptoms of inflammation are redness, swelling, pain, heat and
weakness. Present study was undertaken to investigate phytoconstituents and
antiinflammatory activity of the C. spinarum leave extract. Powdered C.
spinarum leaves were extracted by using soxhlet apparatus with petroleum ether,
chloroform, ethanol and distilled water separately. Formalin induced rat hind
paw edema method was used for analysing pharmacological activity. Group was
divided into seven groups; Group I normal control, Group II formalin control,
Group III standard drug, Group IV, V, VI and VII are test groups. Analgin was
taken as standard drug. 200mg/kg petroleum ether extract, chloroform extract,
ethanol extract and aqueous extract of C spinarum leaves were feed to group IV,
V, VI and VII respectively. All test groups were shown significant
antiinflammatory activity. Aqueous group was exhibited maximum antiinflammatory
activity in compare to other test groups. Antiinflammatory activity of plant is
may be due to presence of some phytoconstituents such as alkaloids, steroids,
tannins, carbohydrates and lipids. In conclusion C. spinarum is having potent
anti-inflammatory activity.
Keywords: Carissa
spinarum, Antiinflammatory effect, Inflammation, Phytoconstituents