Cite this article:
Chelak and Saraf (2016). Preformulation and Formulation Study of Anticancer Principle of Piperine. Journal of Ravishankar University (Part-B: Science), 29(1), pp.187.
PP-F20
Preformulation
and Formulation Study of Anticancer Principle of Piperine
Sanjay Kumar Chelak and
Shailendra Saraf
University Institute of Pharmacy,
P. Ravishankar Shukla University, Raipur 492 010, India
Corresponding author email:
sanjaychelakt62@ gmail.com
[Received
20 January 2016; accepted I February 2016]
Abstract: Piperine is
an alkaloid responsible for the pungency of black pepper and long pepper, along
with chavicine (an isomer of piperine). Piperine increases bioavailability of
many drugs and nutrients by inhibiting various metabolising enzymes. Piper
nigrum L and its active constituent "Piperine"exhibits diverse
pharmacological activities like antihypertensive, antiplatelet, antioxidant,
antitumor, anti-asthmatics, analgesic, anti-inflammatory, anti-diarrheal,
antispasmodic, antidepressants, immuno-modulatory, anticonvulsant,
anti-thyroids, antibacterial, antifungal, hepato- protective, insecticidal and
larvicidal activities etc. Piperine's bioavailability-enhancing property may be
attributed to increased absorption, which may be due to alteration in membrane lipid
dynamics and change in the conformation of enzymes in the intestine. The
approach is novel as the abundantly available natural product piperine is
utilized as precursor for the synthesis of new potential anticancer agents.
This article concludes the bioavailability enhancing property, preformulation
and formulation study and anticancer property of piperine.
Keywords: Piperine,
Piper nigrum L